Iron Deficiency and Deranged Myocardial Energetics in Heart Failure

Michał Tkaczyszyn (), Krzysztof Michał Górniak, Weronika Hanna Lis, Piotr Ponikowski and Ewa Anita Jankowska
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Michał Tkaczyszyn: Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Krzysztof Michał Górniak: Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland
Weronika Hanna Lis: Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland
Piotr Ponikowski: Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Ewa Anita Jankowska: Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland

IJERPH, 2022, vol. 19, issue 24, 1-15

Abstract: Among different pathomechanisms involved in the development of heart failure, adverse metabolic myocardial remodeling closely related to ineffective energy production, constitutes the fundamental feature of the disease and translates into further progression of both cardiac dysfunction and maladaptations occurring within other organs. Being the component of key enzymatic machineries, iron plays a vital role in energy generation and utilization, hence the interest in whether, by correcting systemic and/or cellular deficiency of this micronutrient, we can influence the energetic efficiency of tissues, including the heart. In this review we summarize current knowledge on disturbed energy metabolism in failing hearts as well as we analyze experimental evidence linking iron deficiency with deranged myocardial energetics.

Keywords: iron deficiency; myocardial tissue; energy generation; metabolic derangements (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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