Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study

Jolanta Zalejska-Fiolka, Anna Birková, Tomasz Wielkoszyński, Beáta Hubková, Beata Szlachta, Rafał Fiolka, Urszula Błaszczyk, Aleksandra Kuzan, Andrzej Gamian, Mária Mareková and Michał Toborek
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Jolanta Zalejska-Fiolka: Department of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
Anna Birková: Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia
Tomasz Wielkoszyński: Higher School of Strategic Planning, 41-303 Dąbrowa Górnicza, Poland
Beáta Hubková: Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia
Beata Szlachta: Department of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
Rafał Fiolka: Doctoral School, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
Urszula Błaszczyk: Department of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
Aleksandra Kuzan: Department of Medical Biochemistry, Wrocław Medical University, 50-367 Wrocław, Poland
Andrzej Gamian: Institute of Immunology and Experimental Therapy, 53-114 Wrocław, Poland
Mária Mareková: Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia
Michał Toborek: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33136, USA

IJERPH, 2022, vol. 19, issue 2, 1-15

Abstract: The current study is focused on the influence of hyperglycemia on weight loss in obese premenopausal women. Specifically, the study evaluated the impact of a six-month individualized low-calorie diet combined with moderate exercise on weight reduction and glucose metabolism in obese women with normoglycemia compared to obese women with moderate hyperglycemia. The results indicated that patients with normoglycemia achieved a successful weight loss, which was connected to a decrease in adipose tissue and reflected by diminished content of visceral fat area (VFA) and percent body fat. In contrast, weight reduction in patients with hyperglycemia was connected not only to the loss of VFA but also to undesired decrease in skeletal muscle mass as well as intracellular and total body water. These unfavorable outcomes were observed despite normalization of glucose metabolism reflected by statistically significant lowering glucose, fructosamine, advanced glycation end-products, and HOMA-IR levels. Overall, the obtained results indicate the importance of the measurement of the carbohydrate profile in obese women and the need for an early introduction of weight reduction strategies before the development of hyperglycemia.

Keywords: anthropometric parameters; bioimpedance; extracellular body water (ECW); hyperglycemia; intracellular body water (ICW); total body water (TBW); free fat mass (FFM); visceral fat area (VFA); weight loss (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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