Impact of Exposome Factors on Epidermal Barrier Function in Patients with Obstructive Sleep Apnea Syndrome

Maria Romera-Vilchez, Trinidad Montero-Vilchez, Manuel Herrero-Fernandez, Juan-Angel Rodriguez-Pozo, Gonzalo Jimenez-Galvez, Concepcion Morales-Garcia, Agustin Buendia-Eisman and Salvador Arias-Santiago
Additional contact information
Maria Romera-Vilchez: Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain
Trinidad Montero-Vilchez: Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
Manuel Herrero-Fernandez: Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain
Juan-Angel Rodriguez-Pozo: Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
Gonzalo Jimenez-Galvez: Pneumnology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
Concepcion Morales-Garcia: Pneumnology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
Agustin Buendia-Eisman: Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain
Salvador Arias-Santiago: Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain

IJERPH, 2022, vol. 19, issue 2, 1-12

Abstract: Exposome factors, such as sleep deprivation and diet, could affect skin barrier function. The objectives of this study are to compare skin barrier function between patients with Obstructive Sleep Apnea Syndrome (OSAS) and healthy individuals, and to evaluate the effect of other exposome factors on skin. A cross-sectional study was conducted. Patients with OSAS and healthy volunteers matched by age and sex were included. OSAS severity was assessed by the Apnea-Hypopnea Index (AHI). Validated questionnaires were used to assess diet, anxiety, depression, and psychological stress. Skin barrier function parameters including temperature, erythema, melanin, pH, transepidermal water loss (TEWL), and stratum corneum hydration (SCH) were measured on the volar forearm. A total of 86 participants were included, 56 patients with OSAS and 30 healthy volunteers. TEWL was higher in OSAS patients than in healthy individuals (8.01 vs. 8.68 g·m −2 ·h −1 ). Regarding disease severity, severe patients had higher TEWL values (9.31 vs. 8.46 vs. 7.08 g·m −2 ·h −1 ) compared to moderate and mild patients. Patients with OSAS had significantly lower sleep quality (11.89 vs. 6.47 Pittsburgh Sleep Quality Index score; p < 0.001), poor adherence to the Mediterranean Diet (8.46 vs. 9.77; p = 0.005), and significantly higher anxiety and depression levels than healthy individuals. In conclusion, patients with OSAS may have skin barrier impairment, reflected in higher TEWL values. These patients also have higher levels of anxiety, depression, stress, and a lower adherence to a Mediterranean Diet, all exposome factors that might impact on skin barrier function.

Keywords: anxiety; diet; exposome; Obstructive Sleep Apnea; skin barrier; sleep disorders (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/2/659/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/2/659/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:2:p:659-:d:719601

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().