Muscle-Skeletal Abnormalities and Muscle Oxygenation during Isokinetic Strength Exercise in Heart Failure with Preserved Ejection Fraction Phenotype: A Cross-Sectional Study

Amanda Vale-Lira, Natália Turri-Silva, Kenneth Verboven, João Luiz Quagliotti Durigan, Alexandra Corrêa G. B. de Lima, Martim Bottaro, Gaspar R. Chiappa, Dominique Hansen and Gerson Cipriano
Additional contact information
Amanda Vale-Lira: Rehabilitation Sciences Program, University of Brasília, Brasília 72220-275, Brazil
Natália Turri-Silva: Health and Technologies in Health Sciences Program, University of Brasília, Brasília 72220-275, Brazil
Kenneth Verboven: BIOMED-REVAL (Rehabilitation Research Centre), Faculty of Rehabilitation Sciences, Hasselt University, 3590 Hasselt, Belgium
João Luiz Quagliotti Durigan: Rehabilitation Sciences Program, University of Brasília, Brasília 72220-275, Brazil
Alexandra Corrêa G. B. de Lima: Health and Technologies in Health Sciences Program, University of Brasília, Brasília 72220-275, Brazil
Martim Bottaro: Faculty of Physical Education, University of Brasília, Brasília 70910-900, Brazil
Gaspar R. Chiappa: Human Movement and Rehabilitation Graduate Program, Universidade Evangélica de Goiás, Anápolis 76385-608, Brazil
Dominique Hansen: BIOMED-REVAL (Rehabilitation Research Centre), Faculty of Rehabilitation Sciences, Hasselt University, 3590 Hasselt, Belgium
Gerson Cipriano: Rehabilitation Sciences Program, University of Brasília, Brasília 72220-275, Brazil

IJERPH, 2022, vol. 19, issue 2, 1-25

Abstract: Exercise intolerance, a hallmark of patients with heart failure (HF), is associated with muscle weakness. However, its causative microcirculatory and muscle characteristics among those with preserved or reduced ejection fraction (HFpEF or HFrEF) phenotype is unclear. The musculoskeletal abnormalities that could result in impaired peripheral microcirculation are sarcopenia and muscle strength reduction in HF, implying lowered oxidative capacity and perfusion affect transport and oxygen utilization during exercise, an essential task from the microvascular muscle function. Besides that, skeletal muscle microcirculatory abnormalities have also been associated with exercise intolerance in HF patients who also present skeletal muscle myopathy. This cross-sectional study aimed to compare the muscle microcirculation dynamics via near-infrared spectroscopy (NIRS) response during an isokinetic muscle strength test and ultrasound-derived parameters (echo intensity was rectus femoris muscle, while the muscle thickness parameter was measured on rectus femoris and quadriceps femoris) in heart failure patients with HFpEF and HFrEF phenotypes and different functional severities (Weber Class A, B, and C). Twenty-eight aged-matched patients with HFpEF ( n = 16) and HFrEF ( n = 12) were assessed. We found phenotype differences among those with Weber C severity, with HFrEF patients reaching lower oxyhemoglobin (O 2 Hb, μM) (−10.9 ± 3.8 vs. −23.7 ± 5.7, p = 0.029) during exercise, while HFpEF reached lower O 2 Hb during the recovery period (−3.0 ± 3.4 vs. 5.9 ± 2.8, p = 0.007). HFpEF with Weber Class C also presented a higher echo intensity than HFrEF patients (29.7 ± 8.4 vs. 15.1 ± 6.8, p = 0.017) among the ultrasound-derived variables. Our preliminary study revealed more pronounced impairments in local microcirculatory dynamics in HFpEF vs. HFrEF patients during a muscle strength exercise, combined with muscle-skeletal abnormalities detected via ultrasound imaging, which may help explain the commonly observed exercise intolerance in HFpEF patients.

Keywords: microcirculation; muscle strength; spectroscopy; near-infrared; ultrasonography; heart failure (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/2/709/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/2/709/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:2:p:709-:d:720732

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().