Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Beatrice Ragnoli, Patrizia Pochetti, Patrizia Pignatti, Mariangela Barbieri, Lucrezia Mondini, Luca Ruggero, Liliana Trotta, Paolo Montuschi and Mario Malerba
Additional contact information
Beatrice Ragnoli: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
Patrizia Pochetti: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
Patrizia Pignatti: Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri IRCCS Pavia, 27100 Pavia, Italy
Mariangela Barbieri: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
Lucrezia Mondini: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
Luca Ruggero: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
Liliana Trotta: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
Paolo Montuschi: Pharmacology Department, Faculty of Medicine, Catholic University of the Sacred Heart, 20123 Milan, Italy
Mario Malerba: Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy

IJERPH, 2022, vol. 19, issue 2, 1-15

Abstract: Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species. In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may perturb the delicate balance with severe repercussions on health outcomes. For instance, experimental sleep deprivation studies in vivo have reported several major detrimental effects on immune health, including induced failure of host defense in rats and increased risk for metabolic syndrome (MetS) and immune suppression in humans. In addition, two novel risk factors for dysregulated metabolic physiology have recently been identified: sleep disruption and circadian misalignment. In light of these recent findings about the interplay between sleep and the immune system, in this review, we focus on the relationship between sleep deprivation and immunity against viruses, with a special interest in SARS-CoV-2 infection.

Keywords: sleep deprivation; immune system suppression; SARS-CoV-2 infection (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/2/904/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/2/904/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:2:p:904-:d:724657

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().