Longitudinal Impact of WTC Dust Inhalation on Rat Cardiac Tissue Transcriptomic Profiles

Sung-Hyun Park, Yuting Lu, Yongzhao Shao, Colette Prophete, Lori Horton, Maureen Sisco, Hyun-Wook Lee, Thomas Kluz, Hong Sun, Max Costa, Judith Zelikoff, Lung-Chi Chen, Matthew W. Gorr, Loren E. Wold and Mitchell D. Cohen
Additional contact information
Sung-Hyun Park: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Yuting Lu: Departments of Population Health & Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
Yongzhao Shao: Departments of Population Health & Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
Colette Prophete: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Lori Horton: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Maureen Sisco: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Hyun-Wook Lee: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Thomas Kluz: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Hong Sun: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Max Costa: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Judith Zelikoff: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Lung-Chi Chen: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
Matthew W. Gorr: Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 13210, USA
Loren E. Wold: Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 13210, USA
Mitchell D. Cohen: Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA

IJERPH, 2022, vol. 19, issue 2, 1-16

Abstract: First responders (FR) exposed to the World Trade Center (WTC) Ground Zero air over the first week after the 9/11 disaster have an increased heart disease incidence compared to unexposed FR and the general population. To test if WTC dusts were causative agents, rats were exposed to WTC dusts (under isoflurane [ISO] anesthesia) 2 h/day on 2 consecutive days; controls received air/ISO or air only. Hearts were collected 1, 30, 240, and 360 d post-exposure, left ventricle total RNA was extracted, and transcription profiles were obtained. The data showed that differentially expressed genes (DEG) for WTC vs. ISO rats did not reach any significance with a false discovery rate (FDR) < 0.05 at days 1, 30, and 240, indicating that the dusts did not impart effects beyond any from ISO. However, at day 360, 14 DEG with a low FDR were identified, reflecting potential long-term effects from WTC dust alone, and the majority of these DEG have been implicated as having an impact on heart functions. Furthermore, the functional gene set enrichment analysis (GSEA) data at day 360 showed that WTC dust could potentially impact the myocardial energy metabolism via PPAR signaling and heart valve development. This is the first study showing that WTC dust could significantly affect some genes that are associated with the heart/CV system, in the long term. Even > 20 years after the 9/11 disaster, this has potentially important implications for those FR exposed repeatedly at Ground Zero over the first week after the buildings collapsed.

Keywords: WTC dust; rat cardiac tissue; transcriptomic profiles (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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