Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study

Mathilde Grosselin, Leila Bouazzi, Thomas Ferreira de Moura, Carl Arndt, Maxime Thorigny, Stéphane Sanchez and Alexandre Denoyer
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Mathilde Grosselin: Department of Ophthalmology, University Hospital, University of Reims Champagne-Ardenne, 51100 Reims, France
Leila Bouazzi: Department of Biostatistics and Health Economics, University of Reims Champagne-Ardenne, CURRS, 51100 Reims, France
Thomas Ferreira de Moura: Department of Ophthalmology, University Hospital, University of Reims Champagne-Ardenne, 51100 Reims, France
Carl Arndt: Department of Ophthalmology, University Hospital, University of Reims Champagne-Ardenne, 51100 Reims, France
Maxime Thorigny: Department of Biostatistics and Health Economics, University of Reims Champagne-Ardenne, CURRS, 51100 Reims, France
Stéphane Sanchez: Department of Medical Information, Hospital of Troyes, 10420 Troyes, France
Alexandre Denoyer: Department of Ophthalmology, University Hospital, University of Reims Champagne-Ardenne, 51100 Reims, France

IJERPH, 2022, vol. 19, issue 2, 1-9

Abstract: While exposure to pesticides is a known risk factor for neurodegenerative brain diseases, little is known about the influence of environment on glaucoma neuropathy. We aimed to determine whether farmers are at higher risk of developing severe primary open-angle glaucoma (POAG). This retrospective cohort study (tertiary referral center, Reims University Hospital, France) included patients diagnosed with POAG in the last two years. Univariate analysis and adjusted multivariate logistic regression were performed to evaluate the association between agricultural profession and all recorded data. Glaucoma severity (primary outcome) and the number of patients who underwent filtering surgery (secondary outcome) were analyzed. In total, 2065 records were screened, and 772 patients were included (66 in the farmer group and 706 in the nonfarmer group). The risk of severe glaucoma was higher in the farmer group (adjusted odds ratio (aOR) 1.87, p = 0.03). More patients underwent filtering surgery in the farmer group in univariate analysis ( p = 0.02) but with no statistical significance after adjustment ( p = 0.08). These results suggest pesticide exposure may be a factor accelerating the neurodegeneration in POAG, although a direct link between the agricultural profession and the disease requires further extended studies to be demonstrated.

Keywords: glaucoma; farmer; environment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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