Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study

Victoria A. Metelskaya, Svetlana A. Shalnova, Elena B. Yarovaya, Vladimir A. Kutsenko, Sergey A. Boytsov, Eugeny V. Shlyakhto and Oxana M. Drapkina
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Victoria A. Metelskaya: National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia
Svetlana A. Shalnova: National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia
Elena B. Yarovaya: National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia
Vladimir A. Kutsenko: National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia
Sergey A. Boytsov: National Medical Research Center of Cardiology, 121552 Moscow, Russia
Eugeny V. Shlyakhto: Almazov Federal Medical Research Center, 197341 St. Petersburg, Russia
Oxana M. Drapkina: National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia

IJERPH, 2022, vol. 19, issue 2, 1-14

Abstract: This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions ( n = 13) of the Russian Federation (RF). Randomly selected samples ( n = 22,258, aged 25–64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by routine methods. Statistical analyses were performed using R software (v.3.5.1). The overall dyslipidemia prevalence was 76.1% (76.9/75.3% for men/women). In women, total cholesterol (TC) and low-density lipoprotein (LDL)-C levels gradually increased with age (from 4.72 to 5.93 and from 2.76 to 3.79 mmol/L, respectively); in men, they reached a maximum by 45–54 (5.55 and 3.55 mmol/L, respectively) and then decreased. No differences in high-density lipoprotein (HDL)-C in men of different ages were found, but slight decreases in HDL-C and apo AI were observed in women by 55–64 years. No pronounced associations between education and lipid levels in men were observed; higher-educated women showed significantly better lipoprotein profiles. Similar associations between lipids and income level were detected. Women from rural areas had higher TC and triglycerides than urban residents. Regardless of sex, rural residents had higher HDL-C and apo AI, and reduced apo B/apo AI. Conclusion: Information on the peculiarities of dyslipidemia prevalence and lipoprotein profile depending on sex, age, residential place, and socioeconomic status is useful for assessing the global ASCVD risk, and for risk modeling based on national data.

Keywords: dyslipidemia; ESSE-RF; lipoprotein profile; population-based study; prevalence; socioeconomic status (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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