Fat-Free Mass and Skeletal Muscle Mass Gain Are Associated with Diabetes Remission after Laparoscopic Sleeve Gastrectomy in Males but Not in Females

Ngan Thi Kim Nguyen, Nguyen-Phong Vo, Shih-Yi Huang and Weu Wang
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Ngan Thi Kim Nguyen: International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11301, Taiwan
Nguyen-Phong Vo: International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11301, Taiwan
Shih-Yi Huang: School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11301, Taiwan
Weu Wang: Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11301, Taiwan

IJERPH, 2022, vol. 19, issue 2, 1-11

Abstract: Besides massive body weight loss, laparoscopic sleeve gastrectomy (LSG) causes massive lean mass, including fat-free mass (FFM) and skeletal muscle mass (SM) that present higher metabolic rates in males. This study examines sex differences in FFM and SM changes of type 2 diabetes (T2D) remission at 12 months post-LSG. This cohort study recruited 119 patients (53.7% females) with T2D and obesity (body mass index 42.2 ± 7.0 kg/m 2 ) who underwent LSG. Fat-mass (FM) loss was higher in males than in females (−12.8 ± 6.2% vs. −9.9 ± 5.0%, p = 0.02) after one-year post-operation. Regardless of the weight-loss difference, males had higher FFM and SM gain than did females (12.8 ± 8.0 vs. 9.9 ± 5.0% p = 0.02 and 6.5 ± 4.3% vs. 4.9 ± 6.2%, p = 0.03, respectively). Positive correlations of triglyceride reduction with FM loss (r = 0.47, p = 0.01) and SM gain (r = 0.44, p = 0.02) over 12 months post-operation were observed in males who achieved T2D remission. The T2D remission rate significantly increased 16% and 26% for each additional percentage of FFM and SM gain one year after LSG, which only happened in males. Increased FFM and SM were remarkably associated with T2D remission in males, but evidence lacks for females.

Keywords: laparoscopic sleeve gastrectomy; obesity; diabetes remission; fat mass loss; muscle mass (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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