The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients

Kiduk Kim, Kyoonho Kang, Hyewon Sheol, Jihae Shin, Youngseo Sim, Taehoon Yang, Jeongwon Hwang and Ju-Mi Lee
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Kiduk Kim: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Kyoonho Kang: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Hyewon Sheol: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Jihae Shin: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Youngseo Sim: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Taehoon Yang: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Jeongwon Hwang: Eulji College of Medicine, Eulji University, Daejeon 34824, Korea
Ju-Mi Lee: Department of Preventive Medicine, Eulji College of Medicine, Eulji University, Daejeon 34824, Korea

IJERPH, 2022, vol. 19, issue 3, 1-12

Abstract: Non-alcoholic fatty liver disease (NAFLD) and serum uric acid (SUA) levels are risk factors for developing cardiovascular disease (CVD). Additionally, previous studies have suggested that high SUA levels increase the risk of having NAFLD. However, no study has investigated the relationship between SUA and CVD risk in NAFLD. This study analyzed the relationship between SUA and CVD in NAFLD. Data for this study used the 2016–2018 Korean National Health and Nutrition Examination Survey, which represents the Korean population. A total of 11,160 NAFLD patients were included. Participants with hepatic steatosis index ≥ 30 were considered to have NAFLD. Ten-year CVD risk was estimated using an integer-based Framingham risk score. Estimated 10-year CVD risk ≥ 20% was considered high risk. Multiple logistic regression was conducted to calculate the odds ratios (ORs) associated with SUA level and CVD risk. High CVD risk OR increases by 1.31 (95% CI 1.26–1.37) times per 1 mg/dL of SUA. After adjustment, SUA still had an increased risk (OR 1.44; 95% CI 1.38–1.51) of CVD. Compared with the lowest SUA quartile group, the highest quartile group showed a significantly higher risk of having CVD before (OR 2.76; 95% CI 2.34–3.25) and after (OR 4.01; 95% CI 3.37–4.78) adjustment. SUA is independently associated with CVS risk in NAFLD.

Keywords: non-alcoholic fatty liver disease; uric acid; cardiovascular diseases; heart disease risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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