Non-Epithelial Ovarian Cancers: How Much Do We Really Know?

Alison Cheung, Sidrah Shah, Jack Parker, Pavandeep Soor, Anu Limbu, Matin Sheriff and Stergios Boussios
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Alison Cheung: Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK
Sidrah Shah: Department of Palliative Care, Guy’s and St Thomas’ Hospital, Great Maze Pond, London SE1 9RT, UK
Jack Parker: Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK
Pavandeep Soor: Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK
Anu Limbu: Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK
Matin Sheriff: Department of Urology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK
Stergios Boussios: Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK

IJERPH, 2022, vol. 19, issue 3, 1-18

Abstract: Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely rare tumours, such as small cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. The aetiology and molecular origins of each sub-group of NEOC require further investigation, and our understanding on the genetic changes should be optimised. In this article, we provide an update on the clinical presentation, pathology, genetics, treatment and survival of the main histological subtypes of the GCT and the SCST, as well as of ovarian small cell carcinomas. We also discuss miRNA expression profiles of NEOC and report the currently active clinical trials that include NEOC.

Keywords: germ cell tumours; sex cord-stromal tumours; small cell carcinomas of the ovary; clinical trials (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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