Obesity and Thyroid Cancer Risk: An Update

Fabiana Franchini, Giuseppe Palatucci, Annamaria Colao, Paola Ungaro, Paolo Emidio Macchia and Immacolata Cristina Nettore
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Fabiana Franchini: Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy
Giuseppe Palatucci: Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy
Annamaria Colao: Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy
Paola Ungaro: National Research Council–Institute for Experimental Endocrinology & Oncology ‘Gaetano Salvatore’, 80145 Napoli, Italy
Paolo Emidio Macchia: Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy
Immacolata Cristina Nettore: Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy

IJERPH, 2022, vol. 19, issue 3, 1-15

Abstract: Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence has increased dramatically in recent years. In parallel, the prevalence of overweight and obesity has also increased, suggesting a possible link between these two diseases. Indeed, low-grade chronic inflammation, altered cytokine levels, insulin resistance, oxidative stress, and hormonal changes that occur in obese patients are all factors that contribute to the occurrence and growth of TC. In this review, the most recent evidence supporting the potential role of the mechanisms linking obesity to TC will be discussed.

Keywords: thyroid carcinoma; obesity; overweight; risk factors; cytokines; insulin; insulin resistance; estrogens; oxidative stress (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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