The Distribution of Dengue Virus Serotype in Quang Nam Province (Vietnam) during the Outbreak in 2018

Duong Q. Phan, Linh D. N. Nguyen, Son T. Pham, Tai Nguyen, Phuong T. T. Pham, Suong T. H. Nguyen, Dien T. Pham, Huong T. Pham, Duy K. Tran, Sa H. Le, Tung T. Pham, Kieu C. D. Nguyen, Gianna Dipalma, Alessio Danilo Inchingolo, Prisco Piscitelli, Alessandro Miani, Scacco Salvatore, Stefania Cantore, Sergey K. Aityan, Andrea Ballini, Francesco Inchingolo, Ciro Gargiulo Isacco and Pham Van H.
Additional contact information
Duong Q. Phan: The General Hospital of Quang Nam, Xã Tam Hiệp 51000, Vietnam
Linh D. N. Nguyen: Faculty of Medicine, Phan Chau Trinh University, Danang City 550000, Vietnam
Son T. Pham: School of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
Tai Nguyen: The General Hospital of Quang Nam, Xã Tam Hiệp 51000, Vietnam
Phuong T. T. Pham: Faculty of Medicine, Phan Chau Trinh University, Danang City 550000, Vietnam
Suong T. H. Nguyen: Faculty of Medicine, Phan Chau Trinh University, Danang City 550000, Vietnam
Dien T. Pham: Faculty of Medicine, Phan Chau Trinh University, Danang City 550000, Vietnam
Huong T. Pham: Pham Ngoc Thach University of Medicine, Ho Chi Minh City 70000, Vietnam
Duy K. Tran: NK-Biotek Laboratories, Ho Chi Minh City 70000, Vietnam
Sa H. Le: NK-Biotek Laboratories, Ho Chi Minh City 70000, Vietnam
Tung T. Pham: Faculty of Medicine, Phan Chau Trinh University, Danang City 550000, Vietnam
Kieu C. D. Nguyen: Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Gianna Dipalma: Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Alessio Danilo Inchingolo: Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Prisco Piscitelli: Euro Mediterranean Scientific Biomedical Institute (ISBEM), 72023 Mesagne, Italy
Alessandro Miani: Italian Society of Environmental Medicine (SIMA), 20123 Milan, Italy
Scacco Salvatore: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy
Stefania Cantore: Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Sergey K. Aityan: Department of Multidisciplinary Research Centre, Lincoln University, Oakland, CA 94612, USA
Andrea Ballini: School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Francesco Inchingolo: Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Ciro Gargiulo Isacco: Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Pham Van H.: Faculty of Medicine, Phan Chau Trinh University, Danang City 550000, Vietnam

IJERPH, 2022, vol. 19, issue 3, 1-9

Abstract: Objectives : Quang Nam province in the Centre of Vietnam has faced an outbreak of dengue hemorrhagic fever (DHF) in 2018. Although DHF is a recurrent disease in this area, no epidemiological and microbiological reports on dengue virus serotypes have been conducted mainly due to lack of facilities for such a kind of advanced surveillance. The aim of this study was to detect different dengue virus serotypes in patients’ blood samples. Design and Methods : Suspected cases living in Quang Nam province (Vietnam) and presenting clinical and hematological signs of dengue hemorrhagic fever were included in the study. The screening was performed, and the results were compared by using two methodologies: RT real-time PCR (RT-rPCR) and the Dengue NS1 rapid test. Results : From December 2018 to February 2019, looking both at RT-rPCR [+] and NS1 [+] methodologies, a total of 488 patients were screened and 336 were positive for dengue virus detection (74 children and 262 adults); 273 of these patients (81.3%) underwent viral serotype identification as follows: 12.82% (35/273) D1 serotype, 17.95% (49/273) D2, 0.37% (1/273) D3, 68.50 (187/283) D4, and 0.37% (1/273) D2+D4 serotypes. The RT-rPCR outcomes showed higher sensitivity during the first three days of infection compared to NS1 (92.3% vs. 89.7%). The NS1 increased sensitivity after the first 3 days whilst the RT-rPCR decreased. Conclusions : Advanced surveillance with dengue virus serotypes identification, if performed routinely, may help to predict and prevent further DHF epidemics based on the exposure of the different serotypes during different periods that lead to the intensification of disease severity as a consequence of antibody-dependent enhancement (ADE).

Keywords: dengue hemorrhagic fever; dengue virus serotypes; Quang Nam; Vietnam (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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