The Assessment of Prolonged Inferior Alveolar Nerve Blockade for Postoperative Analgesia in Mandibular Third Molar Surgery by a Perineural Addition of Dexamethasone to 0.5% Ropivacaine: A Randomized Comparison Study

Simona Stojanović, Nikola Burić, Milos Tijanić, Kosta Todorović, Kristina Burić, Nina Burić, Marija Jovanović and Vukadin Bajagić
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Simona Stojanović: Department of Oral Surgery, School of Medicine and Stomatology, University of Niš, 18101 Niš, Serbia
Nikola Burić: Department of Oral Surgery, School of Medicine and Stomatology, University of Niš, 18101 Niš, Serbia
Milos Tijanić: Department of Oral Surgery, School of Medicine and Stomatology, University of Niš, 18101 Niš, Serbia
Kosta Todorović: Department of Oral Surgery, School of Medicine and Stomatology, University of Niš, 18101 Niš, Serbia
Kristina Burić: School of Medicine, University of Niš, 18101 Niš, Serbia
Nina Burić: School of Medicine, University of Niš, 18101 Niš, Serbia
Marija Jovanović: School of Medicine, University of Niš, 18101 Niš, Serbia
Vukadin Bajagić: School of Medicine, University of Podgorica, 81110 Podgorica, Montenegro

IJERPH, 2022, vol. 19, issue 3, 1-17

Abstract: Background: Perineurally adding dexamethasone to local anesthetics could enable postoperative analgesia. Our aim was to investigate the efficacy of 4 mg dexamethasone and 0.5% ropivacaine on the prolonged duration of mandibular anesthesia for postoperative analgesia during third molar surgery. Materials and method: The patients of both sexes, and in the age range of 17 to 50 yrs of age, received the Gow-Gates anesthesia. Group I received 4 mL of plain 0.5% ropivacaine, with perineurally added 1 mL/4 mg of dexamethasone; group II received 4 mL of plain 0.5% ropivacaine with perineurally added 1 mL of 0.9% saline; group III received 4 mL of plain 0.5 bupivacaine with perineurally added 1 mL of 0.9% saline. The prime anesthesia outcome was the duration of conduction anesthesia (DCA); the secondary outcome was the duration of analgesia (DAN) and analgesia before analgesic intake. Results: In 45 randomly selected subjects (mean age 27.06 ± 8.20), DCA was statistically longest in group I ( n = 15) (592.50 ± 161.75 min, p = 0.001), collated with groups II ( n = 15) and III ( n = 15) (307.40 ± 84.71 and 367.07 ± 170.52 min, respectively). DAN was significantly the longest in group I (mean: 654.9 ± 198.4 min, p = 0.001), compared with group II (345.4 ± 88.0 min) and group III (413.7 ± 152.3 min), with insignificant adverse reactions. One-third of the operated patients absented from the use of analgesics. Conclusion: A amount 0.5% ropivacaine with dexamethasone usefully served as an analgesic with a success rate of 93.4% of the given anesthesia.

Keywords: ropivacaine; dexamethasone; prolonged anaesthesia; postoperative analgesia; mandibular anesthesia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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