Assessment of Bi-Ventricular and Bi-Atrial Areas Using Four-Chamber Cine Cardiovascular Magnetic Resonance Imaging: Fully Automated Segmentation with a U-Net Convolutional Neural Network

Hideo Arai, Masateru Kawakubo, Kenichi Sanui, Ryoji Iwamoto, Hiroshi Nishimura and Toshiaki Kadokami
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Hideo Arai: Fukuokaken Saiseikai Futsukaichi Hospital, Chikushino 818-8516, Japan
Masateru Kawakubo: Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Kenichi Sanui: Fukuokaken Saiseikai Futsukaichi Hospital, Chikushino 818-8516, Japan
Ryoji Iwamoto: Fukuokaken Saiseikai Futsukaichi Hospital, Chikushino 818-8516, Japan
Hiroshi Nishimura: Fukuokaken Saiseikai Futsukaichi Hospital, Chikushino 818-8516, Japan
Toshiaki Kadokami: Fukuokaken Saiseikai Futsukaichi Hospital, Chikushino 818-8516, Japan

IJERPH, 2022, vol. 19, issue 3, 1-13

Abstract: Four-chamber (4CH) cine cardiovascular magnetic resonance imaging (CMR) facilitates simultaneous evaluation of cardiac chambers; however, manual segmentation is time-consuming and subjective in practice. We evaluated deep learning based on a U-Net convolutional neural network (CNN) for fully automated segmentation of the four cardiac chambers using 4CH cine CMR. Cine CMR datasets from patients were randomly assigned for training (1400 images from 70 patients), validation (600 images from 30 patients), and testing (1000 images from 50 patients). We validated manual and automated segmentation based on the U-Net CNN using the dice similarity coefficient (DSC) and Spearman’s rank correlation coefficient ( ρ ); p < 0.05 was statistically significant. The overall median DSC showed high similarity (0.89). Automated segmentation correlated strongly with manual segmentation in all chambers—the left and right ventricles, and the left and right atria (end-diastolic area: ρ = 0.88, 0.76, 0.92, and 0.87; end-systolic area: ρ = 0.81, 0.81, 0.92, and 0.83, respectively; p < 0.01). The area under the curve for the left ventricle, left atrium, right ventricle, and right atrium showed high scores (0.96, 0.99, 0.88, and 0.96, respectively). Fully automated segmentation could facilitate simultaneous evaluation and detection of enlargement of the four cardiac chambers without any time-consuming analysis.

Keywords: cardiovascular magnetic resonance imaging; four-chamber cine imaging; fully automatic cardiac segmentation; heart chamber enlargement; convolutional neural network; U-Net (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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