Optimization of Ultrasonic-Assisted Extraction of Chlorogenic Acid from Tobacco Waste

Guoming Zeng, Yujie Ran, Xin Huang, Yan Li, Maolan Zhang, Hui Ding, Yonggang Ma, Hongshuo Ma, Libo Jin and Da Sun
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Guoming Zeng: Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
Yujie Ran: Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
Xin Huang: Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
Yan Li: School of Pharmacy, Taizhou Polytechnic College, Taizhou 225300, China
Maolan Zhang: Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
Hui Ding: Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
Yonggang Ma: School of Pharmacy, Taizhou Polytechnic College, Taizhou 225300, China
Hongshuo Ma: Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
Libo Jin: Biomedical Collaborative Innovation Center of Zhejiang Province, Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China
Da Sun: Biomedical Collaborative Innovation Center of Zhejiang Province, Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China

IJERPH, 2022, vol. 19, issue 3, 1-10

Abstract: Using tobacco waste as raw material, the ultrasonic-assisted extraction of chlorogenic acid was optimized by response surface methodology (RSM). After repeated freezing and thawing of tobacco waste twice, the effect of pH value, ethanol volume fraction, temperature and extraction time on the extraction rate of chlorogenic acid was investigated by a single factor experiment. On the basis of this, the factors affecting the yield of chlorogenic acid were further optimized by using RSM. The optimum extraction conditions for chlorogenic acid were set at pH = 4.1, ethanol volume fraction was 49.57% and extraction time was 2.06 h. Under the above conditions, the extraction rate of chlorogenic acid could reach 0.502%, which was higher than traditional extraction and unpretreated ultrasonic extraction. All these results can be used as a reference for the extraction of effective ingredients in tobacco waste.

Keywords: waste treatment; chlorogenic acid; optimal design; preprocessing; ultrasonic-assisted extraction (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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