Natural Bioactive Compounds in the Management of Oral Diseases in Nephropathic Patients

Michele Basilicata, Manuela Di Lauro, Vincenzo Campolattano, Giulia Marrone, Roberto Celotto, Anna Paola Mitterhofer, Patrizio Bollero, Nicola Di Daniele and Annalisa Noce
Additional contact information
Michele Basilicata: UOSD Special Care Dentistry, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00100 Rome, Italy
Manuela Di Lauro: UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Vincenzo Campolattano: UOSD Special Care Dentistry, Department of Dentistry and Dental Prosthesis, University of Rome Tor Vergata, 00133 Rome, Italy
Giulia Marrone: UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Roberto Celotto: Department of Cardiovascular Disease, University of Rome Tor Vergata, 00133 Rome, Italy
Anna Paola Mitterhofer: Nephrology and Dialysis Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Patrizio Bollero: UOSD Special Care Dentistry, Department of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy
Nicola Di Daniele: UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Annalisa Noce: UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy

IJERPH, 2022, vol. 19, issue 3, 1-16

Abstract: Among the chronic non-communicable degenerative diseases (CDNCDs), chronic kidney disease (CKD) represents a global public health problem. Recent studies demonstrate a mutual cause–effect relationship between CKD and oral diseases, in which the presence of one induces the onset and faster progression of the other. In particular, the oral cavity alterations more frequent in CKD patients are: chronic periodontitis diseases, bone lesions, oral infections, and oral cancer lesions. Currently, a standardized therapy for the treatment of oral diseases is lacking. For this reason, natural bioactive compounds (NBCs), characterized by several health effects, such as antioxidant, antimicrobial, anti-inflammatory and anti-cancer actions, represent a new possible adjuvant therapy in the management of these pathological conditions. Among NBCs, polyphenols play a leading role due to positive modulation of oral microbiota, preventing and correcting oral dysbiosis. Moreover, these compounds exert anti-inflammatory effects, such as inhibiting the production of pro-inflammatory cytokines and the expression of cycloxigenase-2. In this light, the formulation of a new mouthwash/gel/gingival paste, with a high content of polyphenols in association with NBCs characterized by antimicrobial action, could represent a future therapy of oral disease in CKD patients.

Keywords: chronic kidney disease; chronic periodontitis diseases; polyphenols; oral microbiota; renal replacement therapy; special care dentistry (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/3/1665/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/3/1665/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:3:p:1665-:d:739939

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().