Potential Toxic Effects of Exposure to Titanium Silicon Oxide Nanoparticles in Male Rats

Shimaa Ghareeb, Didair Ragheb, Aly El-Sheakh and Mohamed-Bassem Ali Ashour
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Shimaa Ghareeb: Laboratory of Pest Physiology, Plant Protection Research Institute, Zagazig Branch, Agricultural Research Center, Ministry of Agriculture and Land Reclamation, Giza 12618, Egypt
Didair Ragheb: Molecular and Environmental Toxicology Research Laboratory, Plant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt
Aly El-Sheakh: Laboratory of Pest Physiology, Plant Protection Research Institute, Zagazig Branch, Agricultural Research Center, Ministry of Agriculture and Land Reclamation, Giza 12618, Egypt
Mohamed-Bassem Ali Ashour: Molecular and Environmental Toxicology Research Laboratory, Plant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt

IJERPH, 2022, vol. 19, issue 4, 1-19

Abstract: Recently, nano titanium silicon oxide (TiSiO 4 NPs) has been used in different fields and industries. Very few toxicological data exist for TiSiO 4 NPs. In the present study, the potential adverse effects of oral exposure to a single dose of TiSiO 4 NPs ≤ 50 nm (250 mg/kg b.w.) in adult male rats were investigated through the assessment of biomarkers for serum biochemical parameters, liver DNA damage, and histopathological examination and determination of Si and Ti in the exposed rat tissues. The results revealed that there were no significant changes in serum total protein, albumin, and triglycerides content, while total cholesterol level was significantly increased 7 days after exposure. TiSiO 4 NPs significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPx), acetylcholine esterase (AChE), lactate dehydrogenase (LDH) activity, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels in the exposed rat serum, whereas alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, urea level, immunoglobulins (IgG and IgM) concentrations, progesterone, and testosterone levels were significantly decreased. The liver comet assay indices were significantly increased after 7 days post-exposure. Moreover, histopathological changes and the accumulation of Si and Ti in liver, kidney, spleen, and lung tissues of treated rats were recorded.

Keywords: TiSiO 4 NPs toxicity; male rats; serum biomarkers; oxidative stress; genotoxicity; immune toxicity; hepatotoxicity; renal toxicity; reproductive toxicity; histological alterations; Si and Ti accumulation in rat tissues (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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