Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review

Romina Fakhraei, Kathryn Denize, Alexandre Simon, Ayni Sharif, Julia Zhu-Pawlowsky, Alysha L. J. Dingwall-Harvey, Brian Hutton, Misty Pratt, Becky Skidmore, Nadera Ahmadzai, Nicola Heslehurst, Louise Hayes, Angela C. Flynn, Maria P. Velez, Graeme Smith, Andrea Lanes, Natalie Rybak, Mark Walker and Laura Gaudet
Additional contact information
Romina Fakhraei: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Kathryn Denize: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Alexandre Simon: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Ayni Sharif: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Julia Zhu-Pawlowsky: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Alysha L. J. Dingwall-Harvey: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Brian Hutton: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Misty Pratt: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Becky Skidmore: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Nadera Ahmadzai: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Nicola Heslehurst: Institute of Health & Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
Louise Hayes: Institute of Health & Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
Angela C. Flynn: Department of Women and Children’s Health, King’s College London, London WC2R 2LS, UK
Maria P. Velez: Department of Obstetrics and Gynecology, Queen’s University, Kingston, ON K7L 3N6, Canada
Graeme Smith: Department of Obstetrics and Gynecology, Queen’s University, Kingston, ON K7L 3N6, Canada
Andrea Lanes: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Natalie Rybak: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Mark Walker: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Laura Gaudet: Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada

IJERPH, 2022, vol. 19, issue 4, 1-23

Abstract: Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome ( n = 32), followed by preterm birth ( n = 29), preeclampsia ( n = 27), low birthweight infants ( n = 20), small for gestational age newborns ( n = 12), and stillbirth ( n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age < 20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.

Keywords: obesity; pregnancy; adverse outcomes; predictors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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