Etanercept Prevents Endothelial Dysfunction in Cafeteria Diet-Fed Rats

Scăunaşu Răzvan-Valentin, Sertaç Ata Güler, Tijen Utkan, Tuğçe Demirtaş Şahin, Gulcin Gacar, Yusufhan Yazir, Selenay Furat Rencber, Lupușoru Mircea, Bălălău Cristian, Popescu Bogdan and Nihat Zafer Utkan
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Scăunaşu Răzvan-Valentin: Department of General Surgery, Faculty of General Medicine, “Coltea” Hospital, Carol Davila University, 020021 Bucharest, Romania
Sertaç Ata Güler: Department of General Surgery, Medical Faculty, Kocaeli University, Kocaeli 41380, Turkey
Tijen Utkan: Department of Pharmacology, Medical Faculty, Kocaeli University, Kocaeli 41380, Turkey
Tuğçe Demirtaş Şahin: Department of Pharmacology, Medical Faculty, Kocaeli University, Kocaeli 41380, Turkey
Gulcin Gacar: Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, Kocaeli 41380, Turkey
Yusufhan Yazir: Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, Kocaeli 41380, Turkey
Selenay Furat Rencber: Department of Histology and Embryology, Medical Faculty, Kocaeli University, Kocaeli 41380, Turkey
Lupușoru Mircea: Department of General Surgery, Faculty of General Medicine, “Coltea” Hospital, Carol Davila University, 020021 Bucharest, Romania
Bălălău Cristian: Department of General Surgery, Faculty of General Medicine, “Coltea” Hospital, Carol Davila University, 020021 Bucharest, Romania
Popescu Bogdan: Department of General Surgery, Faculty of General Medicine, “Coltea” Hospital, Carol Davila University, 020021 Bucharest, Romania
Nihat Zafer Utkan: Department of General Surgery, Medical Faculty, Kocaeli University, Kocaeli 41380, Turkey

IJERPH, 2022, vol. 19, issue 4, 1-15

Abstract: Obesity is associated with endothelial dysfunction and this relationship is probably mediated in part by inflammation. Objective: The current study evaluated the effects of etanercept, a tumor necrosis factor-alpha (TNF-α) inhibitor, on endothelial and vascular reactivity, endothelial nitric oxide synthase (eNOS) immunoreactivity, and serum and aortic concentrations of TNF-α in a diet-induced rat model. Design and results: Male weanling Wistar rats were exposed to a standard diet and cafeteria diet (CD) for 12 weeks and etanercept was administered during CD treatment. Isolated aortas of the rats were used for isometric tension recording. Carbachol-induced relaxant responses were impaired in CD-fed rats, while etanercept treatment improved these endothelium-dependent relaxations. No significant change was observed in papaverine- and sodium nitroprusside (SNP)-induced relaxant responses. eNOS expression decreased in CD-fed rats, but no change was observed between etanercept-treated CD-fed rats and control rats. CD significantly increased both the serum and the aortic levels of TNF-α, while etanercept treatment suppressed these elevated levels. CD resulted in a significant increase in the body weight of the rats. Etanercept-treated (ETA) CD-fed rats gained less weight than both CD-fed and control rats.

Keywords: cafeteria diet; endothelial dysfunction; etanercept; inflammation; nitric oxide TNF-? (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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