Predictive and Diagnostic Value of Serum Adipokines in Pregnant Women with Intrahepatic Cholestasis

Nazan Yurtcu, Canan Soyer Caliskan, Huri Guvey, Samettin Celik, Safak Hatirnaz and Andrea Tinelli
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Nazan Yurtcu: Department of Obstetrics and Gynecology, Sivas Cumhuriyet University Faculty of Medicine, Sivas 58140, Turkey
Canan Soyer Caliskan: Department of Obstetrics and Gynecology, Samsun Training and Research Hospital, Health Sciences University, Samsun 55270, Turkey
Huri Guvey: Department of Obstetrics and Gynecology, Private Kütahya Parkhayat Hospital, Kütahya 43100, Turkey
Samettin Celik: Department of Obstetrics and Gynecology, Samsun Training and Research Hospital, Health Sciences University, Samsun 55270, Turkey
Safak Hatirnaz: In Vitro Fertilization Unit, Medicana International Hospital, Samsun 55080, Turkey
Andrea Tinelli: Department of Obstetrics and Gynecology, Veris delli Ponti Hospital, 73020 Lecce, Italy

IJERPH, 2022, vol. 19, issue 4, 1-13

Abstract: The objective of this study was to assess the value of serum leptin, adiponectin, apelin, and ghrelin as biomarkers for the prediction and diagnosis of intra-hepatic cholestasis (ICP). This prospective study included pregnant women in the third trimester of pregnancy: 63 with ICP, 48 and 15 of whom had mild and severe disease, respectively, and 32 as controls. ICP women had increased median levels of serum leptin, adiponectin, apelin, and ghrelin compared to the controls ( p < 0.05). These biomarkers meaningfully changed regarding the severity of ICP: While leptin was reduced, apelin and ghrelin were increased, and adiponectin was increased somewhat. To predict and diagnose ICP, the predictive values of serum leptin, adiponectin, and apelin need to be accepted as comparable, with moderate to high sensitivity and specificity; however, the predictive value of serum ghrelin was somewhat lower. More research is needed to clarify the potential properties of adipokines to gain acceptance as a predictive or diagnostic biomarker for ICP.

Keywords: intrahepatic cholestasis of pregnancy; adipokines; leptin; adiponectin; apelin; ghrelin; complications (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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