Clinical Presentation and Mortality of Severe Fever with Thrombocytopenia Syndrome in Japan: A Systematic Review of Case Reports

Kanako Yokomizo, Momoko Tomozane, Chiaki Sano and Ryuichi Ohta
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Kanako Yokomizo: Faculty of Medicine, Shimane University, Izumo 693-8501, Japan
Momoko Tomozane: Department of Postgraduate Medical Education, Japanese Red Cross Society Himeji Hospital, Himeji 670-8540, Japan
Chiaki Sano: Faculty of Medicine, Shimane University, Izumo 693-8501, Japan
Ryuichi Ohta: Community Care, Unnan City Hospital, Unnan 699-1221, Japan

IJERPH, 2022, vol. 19, issue 4, 1-12

Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an infection mediated by ticks and has been reported to have a high mortality rate in Japan. At our hospital, we reported three cases of SFTS with relatively positive outcomes. We reviewed reports of SFTS cases in Japan to clarify the current state of the disease in Japan, the treatment provided, and its outcome. The Ichushi Web was searched for literature using the following terms as keywords: “SFTS” or “severe fever with thrombocytopenia syndrome”. Overall, 174 cases were collected and reviewed. The mean age of patients was 70.69 years old, and the mortality rate was 35%. The dead group was significantly older ( p < 0.001) than the alive group, had a significantly shorter period from symptom onset to hospital admission, and experienced significantly more hemorrhage-related and neurological symptoms. Further, the most frequently provided treatment methods were adrenocorticosteroids, antibiotics, and conservative treatment. The low recognition rate of SFTS in Japan might lead to a misdiagnosis or delay in diagnosis and treatment, especially in mild to moderate cases. Medical professionals and citizens who live in areas inhabited by ticks need to be informed about SFTS to appropriately diagnose and manage SFTS cases in Japan in the future.

Keywords: severe fever with thrombocytopenia syndrome (SFTS); systematic review; Japan; mortality; hospital admission; recognition (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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