Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition?

Tomasz Gołębiowski, Jakub Kuźniar, Tomasz Porażko, Renata Wojtala, Andrzej Konieczny, Magdalena Krajewska and Marian Klinger
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Tomasz Gołębiowski: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
Jakub Kuźniar: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
Tomasz Porażko: Department of Internal Medicine and Nephrology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland
Renata Wojtala: Departament of Patomorphology, Wroclaw Medical University, 50-556 Wroclaw, Poland
Andrzej Konieczny: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
Magdalena Krajewska: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
Marian Klinger: Department of Internal Medicine and Nephrology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland

IJERPH, 2022, vol. 19, issue 4, 1-8

Abstract: The over-secretion of monoclonal immunoglobulin light chains by clonal B cells followed by the aggregation and extracellular deposition of fibrillar deposits are responsible forthe clinical course AL amyloidosis. It is well documented that silica significantly increases the number of immunoglobulin-secreting cells. In the present paper, we report on a coal miner with silicosis and fast progressing primary amyloidosis with predominantly heart, kidney, and lung manifestations. Severeheart failure due to myocardial hypertrophy resulted in the patient’s death. We conclude that long-term environmental silica exposure and silica deposition may contribute to the development of monoclonal gammopathy and amyloidosis due to chronic stimulus and the dysregulation of the immune system.

Keywords: silicosis; primary amyloidosis; heart insufficiency; kidney insufficiency; proteinuria (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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