The Gram-Negative Bacilli Isolated from Caves— Sphingomonas paucimobilis and Hafnia alvei and a Review of Their Involvement in Human Infections

Mihaela Ileana Ionescu, Dan Ștefan Neagoe, Alexandra Marioara Crăciun and Oana Teodora Moldovan
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Mihaela Ileana Ionescu: Iuliu Hațieganu University of Medicine and Pharmacy, 6 Louis Pasteur, 400349 Cluj-Napoca, Romania
Dan Ștefan Neagoe: Department of Microbiology, County Emergency Clinical Hospital, 400006 Cluj-Napoca, Romania
Alexandra Marioara Crăciun: Iuliu Hațieganu University of Medicine and Pharmacy, 6 Louis Pasteur, 400349 Cluj-Napoca, Romania
Oana Teodora Moldovan: Emil Racovita Institute of Speleology, Cluj-Napoca Department, Clinicilor 5, 400006 Cluj-Napoca, Romania

IJERPH, 2022, vol. 19, issue 4, 1-21

Abstract: The opportunistic infections with Gram-negative bacilli are frequently reported. The clinical studies are focused on the course of human infectious and very often the source of infection remain unclear. We aim to see if the Gram-negative bacilli isolated from a non-contaminated environment—the caves—are reported in human infections. Eleven samples were collected from six Romanian caves. We used the standard procedure used in our clinical laboratory for bacterial identification and for antibiotic susceptibility testing of the cave isolates. Out of the 14 bacterial strains, three isolates are Gram-negative bacilli—one isolate belong to Hafnia alvei and two strains belong to Sphingomonas paucimobilis . We screened for the published studies—full-text original articles or review articles—that reported human infections with S. paucimobilis and H. alvei. Data sources—PubMed and Cochrane library. We retrieved 447 cases from 49 references—262 cases (58.61%) are S. paucimobilis infections and 185 cases (41.39%) are H. alvei infections. The types of infections are diverse but there are some infections more frequent; there are 116 cases (44.27%) and many infections of the bloodstream with S. paucimobilius (116 cases) and 121 cases (65.41%) are urinary tract infections with H. alvei . The acquired source of the bloodstream infections is reported for 93 of S. paucimobilis bloodstream infections—50 cases (43%) are hospital-acquired, and 40 cases (37%) are community-acquired. Most of the infections are reported in patients with different underlying conditions. There are 80 cases (17.9%) are reported of previously healthy persons. Out of the 72 cases of pediatric infections, 62 cases (86.11%) are caused by S. paucimobilis . There are ten death casualties—three are H. alvei infections, and seven are S. paucimobilis infections.

Keywords: Sphingomonas paucimobilis; Hafnia alvei; cave environment; bloodstream infections; urinary tract infections; pediatric infections; opportunistic infections; colistin resistance; innate antibiotic resistance; identification methods (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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