Relationship between Using Fibrate and Open-Angle Glaucoma in Hyperlipidemic Patients: A Population-Based Cohort Study

Yung-En Tsai, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Wu-Chien Chien and Ke-Hung Chien
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Yung-En Tsai: Department of Ophthalmology, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
Yi-Hao Chen: Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Chien-An Sun: Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan
Chi-Hsiang Chung: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Wu-Chien Chien: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Ke-Hung Chien: Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan

IJERPH, 2022, vol. 19, issue 4, 1-9

Abstract: Background: This study aimed to investigate the associated risk between using fibrate and open-angle glaucoma (OAG) in hyperlipidemic patients from the National Health Insurance Research Database (NHIRD). Methods: We collected data over a 16-year period from the NHIRD, and used the Fisher’s exact test and Pearson chi-square test to analyze variables. Adjusted hazard ratios (aHR) were used to examine the risk factors for disease development. We applied Kaplan–Meier analysis to compare the cumulative incidence of OAG. Results: A total of 10,011 patients using fibrate were enrolled in the study cohort, and 40,044 patients not using fibrate were enrolled in the control cohort. The incidence of OAG was lower in the study cohort than in the control cohort (aHR = 0.624, p = 0.007). The overall incidence of OAG was 463.02 per 100,000 person-years in the study cohort and 573.65 per 100,000 person-years in the control cohort. We used the Kaplan–Meier method to calculate the cumulative risk of developing OAG. The results revealed that after using fibrate for over seven years, the study cohort had a greatly lower rate of developing OAG than the control cohort (log-rank test p = 0.050). Conclusions: Our studies showed that using fibrate for over seven years may lead to a lower risk of OAG in patients with hyperlipidemia. Nevertheless, further prospective studies that comprehensively investigate the relationship between using fibrate and OAG are needed.

Keywords: fibrate; open-angle glaucoma; cohort study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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