Epidemiology of Fungal Colonization in Children Treated at the Department of Oncology and Hematology: Single-Center Experience

Joanna Klepacka, Zuzanna Zakrzewska, Małgorzata Czogała, Magdalena Wojtaszek-Główka, Emil Krzysztofik, Wojciech Czogała and Szymon Skoczeń
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Joanna Klepacka: Department of Microbiology, University Children’s Hospital, Wielicka 265, 30-663 Krakow, Poland
Zuzanna Zakrzewska: Department of Oncology and Hematology, University Children’s Hospital, Wielicka 265, 30-663 Krakow, Poland
Małgorzata Czogała: Department of Oncology and Hematology, University Children’s Hospital, Wielicka 265, 30-663 Krakow, Poland
Magdalena Wojtaszek-Główka: Student Scientific Group of Pediatric Oncology and Hematology, Jagiellonian University Medical College, 30-663 Krakow, Poland
Emil Krzysztofik: Student Scientific Group of Pediatric Oncology and Hematology, Jagiellonian University Medical College, 30-663 Krakow, Poland
Wojciech Czogała: Department of Microbiology, University Children’s Hospital, Wielicka 265, 30-663 Krakow, Poland
Szymon Skoczeń: Department of Microbiology, University Children’s Hospital, Wielicka 265, 30-663 Krakow, Poland

IJERPH, 2022, vol. 19, issue 4, 1-11

Abstract: Oncological patients are especially predisposed to fungal infections due to multiple risk factors and immunocompromising treatment. Epidemiological research regarding pediatric oncologic patients is still insufficient, and existing data are difficult to generalize on different populations. Therefore, we aimed to analyze fungal infections and fungal epidemiology in the Department of Oncology and Hematology of the University Children’s Hospital in Krakow with help from the Clinical Microbiology Department. During the chosen period of 2005 and 2015–2020, 2342 tests were performed in our ward on 847 patients. Analyzed samples were divided into five source groups. The amount of patients with positive test results was 62.5%. The year with the highest detection level was 2005. The most frequent pathogen was Candida albicans , with a significant decrease in tendency. An increase in non-albicans species was observed. Candida parapsilosis was not frequently observed compared to similar studies. We noticed an increase in positive results from the urinary tract material. Our results confirmed that fungal infections are still an issue, and they may indicate the efficacy of prophylaxis. The majority of our results are consistent with the literature, yet we managed to emphasize data unique to our patients’ population. Our findings are helpful in clinical work and for further studies in our center.

Keywords: fungal infection; mycology; hematology; pediatric oncology; yeast; Candida spp.; Candida albicans; candidiasis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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