The Salvador Primary Care Longitudinal Study of Child Development (CohortDICa) Following the Zika Epidemic: Study Protocol

Darci Neves Santos, Tânia Maria de Araújo, Leticia Marques dos Santos, Hannah Kuper, Rosana Aquino, Ismael Henrique Da Silveira, Samilly Silva Miranda, Marcos Pereira and Guilherme Loureiro Werneck
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Darci Neves Santos: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador 40110-040, Brazil
Tânia Maria de Araújo: Núcleo de Epidemiologia, Universidade Estadual de Feira de Santana, Feira de Santana 44036-900, Brazil
Leticia Marques dos Santos: Instituto de Humanidades, Artes e Ciências, Universidade Federal da Bahia, Salvador 40170-115, Brazil
Hannah Kuper: International Centre for Evidence in Disability, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
Rosana Aquino: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador 40110-040, Brazil
Ismael Henrique Da Silveira: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador 40110-040, Brazil
Samilly Silva Miranda: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador 40110-040, Brazil
Marcos Pereira: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador 40110-040, Brazil
Guilherme Loureiro Werneck: Departamento de Epidemiologia, Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20559-900, Brazil

IJERPH, 2022, vol. 19, issue 5, 1-11

Abstract: This article describes the Salvador Primary Care Longitudinal Study of Child Development (CohortDICa). The exposed group was defined by confirmation of Congenital Zika Syndrome (CZS) diagnosed through computed tomography, magnetic resonance or transfontanellar ultrasound. A random selection of the 169 exposed children led to a subgroup of 120 children who were paired with children from the Live Birth Information System, according to birthdate, residence in the same street or neighborhood, and gestational age, resulting in 115 subjects in the non-exposed group. Following recruitment and before the participants completed 42 months, three measures were applied to assess cognitive, motor, and language performance, corresponding to three home visits. Social characteristics of the families and children, and the neurocognitive development of the children will be compared across the CZS exposed group ( n = 147), the typical children with no exposure to CZS ( n = 115) and the STORCH exposed group (Syphilis, Toxoplasma gondii, Rubella, Cytomegalovirus, and Herpes simplex) ( n = 20). Primary Health Care (PHC) should include long-term care strategies for the care of children and family members, and might benefit from the research, teaching, and extension activities provided in this study. In the face of the consequences of the Zika virus epidemic, an opportunity arose to intervene in the integrated care of child development within PHC, including, on an equal basis, typical children and those with delays or disabilities in the first six years of life.

Keywords: cohort studies; Zika virus infection; child; microcephaly; Congenital Zika Syndrome; neurocognitive development; primary health care (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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