Importance and Reality of TDM for Antibiotics Not Covered by Insurance in Japan

Fumiya Ebihara, Yukihiro Hamada, Hideo Kato, Takumi Maruyama and Toshimi Kimura
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Fumiya Ebihara: Department of Pharmacy, Tokyo Women’s Medical University Hospital, Tokyo 162-8666, Japan
Yukihiro Hamada: Department of Pharmacy, Tokyo Women’s Medical University Hospital, Tokyo 162-8666, Japan
Hideo Kato: Department of Pharmacy, Mie University Hospital, Mie 514-8507, Japan
Takumi Maruyama: Department of Pharmacy, Tokyo Women’s Medical University Hospital, Tokyo 162-8666, Japan
Toshimi Kimura: Department of Pharmacy, Tokyo Women’s Medical University Hospital, Tokyo 162-8666, Japan

IJERPH, 2022, vol. 19, issue 5, 1-19

Abstract: Under the Japanese health insurance system, medicines undergoing therapeutic drug monitoring (TDM) can be billed for medical fees if they meet the specified requirements. In Japan, TDM of vancomycin, teicoplanin, aminoglycosides, and voriconazole, which are used for the treatment of infectious diseases, is common practice. This means the levels of antibiotics are measured in-house using chromatography or other methods. In some facilities, the blood and/or tissue concentrations of other non-TDM drugs are measured by HPLC and are applied to treatment, which is necessary for personalized medicine. This review describes personalized medicine based on the use of chromatography as a result of the current situation in Japan.

Keywords: HPLC; TDM; ceftriaxone; daptomycin; linezolid (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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