Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography

Marta Román, Javier Louro, Margarita Posso, Carmen Vidal, Xavier Bargalló, Ivonne Vázquez, María Jesús Quintana, Rodrigo Alcántara, Francina Saladié, Javier del Riego, Lupe Peñalva, Maria Sala, Xavier Castells and on behalf of the BELE and IRIS Study Groups
Additional contact information
Marta Román: Epidemiology and Evaluation Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Javier Louro: Epidemiology and Evaluation Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Margarita Posso: Epidemiology and Evaluation Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Carmen Vidal: Cancer Prevention and Monitoring Program, Catalan Institute of Oncology (ICO), 08908 Barcelona, Spain
Xavier Bargalló: Department of Radiology, Hospital Clinic, 08036 Barcelona, Spain
Ivonne Vázquez: Pathology Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
María Jesús Quintana: Department of Clinical Epidemiology and Public Health, University Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
Rodrigo Alcántara: Radiology Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Francina Saladié: Epidemiology and Cancer Prevention Service, Hospital Universitari Sant Joan de Reus, IISPV, 43204 Reus, Spain
Javier del Riego: Department of Radiology, Parc Taulí University Hospital-UAB, 08208 Sabadell, Spain
Lupe Peñalva: Breast Cancer Screening Technical Office, Private Foundation Asil Hospital, 08402 Granollers, Spain
Maria Sala: Epidemiology and Evaluation Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Xavier Castells: Epidemiology and Evaluation Department, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
on behalf of the BELE and IRIS Study Groups: Membership of the BELE and IRIS study groups is provided in the Acknowledgements section.

IJERPH, 2022, vol. 19, issue 5, 1-11

Abstract: Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50–69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.

Keywords: breast neoplasms; mass screening; longitudinal studies; benign breast disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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