Potential Effects of Romanian Propolis Extracts against Pathogen Strains

Mihaela Laura Vică, Mirel Glevitzky, Ramona Cristina Heghedűş-Mîndru, Ioana Glevitzky, Horea Vladi Matei, Stefana Balici, Maria Popa and Cosmin Adrian Teodoru
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Mihaela Laura Vică: Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Mirel Glevitzky: Faculty of Exact Science and Engineering, “1 Decembrie 1918” University of Alba Iulia, 510009 Alba Iulia, Romania
Ramona Cristina Heghedűş-Mîndru: Faculty of Food Processing Technology Banat’s, University of Agricultural Sciences and Veterinary Medicine, 300645 Timișoara, Romania
Ioana Glevitzky: Doctoral School, Faculty of Engineering, “Lucian Blaga” University of Sibiu, 550025 Sibiu, Romania
Horea Vladi Matei: Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Stefana Balici: Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Maria Popa: Faculty of Exact Science and Engineering, “1 Decembrie 1918” University of Alba Iulia, 510009 Alba Iulia, Romania
Cosmin Adrian Teodoru: Clinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550025 Sibiu, Romania

IJERPH, 2022, vol. 19, issue 5, 1-15

Abstract: The impact of globalization on beekeeping brings new economic, scientific, ecological and social dimensions to this field The present study aimed to evaluate the chemical compositions of eight propolis extracts from Romania, and their antioxidant action and antimicrobial activity against seven species of bacteria, including pathogenic ones: Staphylococcus aureus , Bacillus cereus , Bacillus subtilis , Pseudomonas aeruginosa , Escherichia coli , Listeria monocytogenes and Salmonella enterica serovar Typhimurium. The phenolic compounds, flavonoids and antioxidant activity of propolis extracts were quantified; the presence of flavones and aromatic acids was determined. Quercetin and rutin were identified by HPLC analysis and characterized using molecular descriptors. All propolis samples exhibited antibacterial effects, especially against P. aeruginosa and L. monocytogenes . A two-way analysis of variance was used to evaluate correlations among the diameters of the inhibition zones, the bacteria used and propolis extracts used. Statistical analysis demonstrated that the diameter of the inhibition zone was influenced by the strain type, but no association between the propolis origin and the microbial activity was found.

Keywords: propolis; chemical composition; HPLC; rutin; quercetin; molecular descriptors; antioxidant activity; antimicrobial activity; pathogenic bacteria (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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