Isolated Hypoglossal Nerve Palsy as an Early Symptom of a Granular Cell Tumor

Juliana Lemound, Dimitrios Papadimas, Sabine Skodda, Andrea Tannapfel, Anriy Alekseyev and Martin Kunkel
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Juliana Lemound: Department of Oral and Maxillofacial Surgery, Ruhr University Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany
Dimitrios Papadimas: Department of Oral and Maxillofacial Surgery, Klinikum Saarbrücken, 66119 Saarbrücken, Germany
Sabine Skodda: Department of Neurology, Ruhr University Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany
Andrea Tannapfel: Department of Pathology, University of Bochum Medical Center, Ruhr University Klinikum Bergmannsheil Bochum, 44789 Bochum, Germany
Anriy Alekseyev: Department for Radiology, Krankenhaus Wermelskirchen, 42929 Wermelskirchen, Germany
Martin Kunkel: Department of Oral and Maxillofacial Surgery, Ruhr University Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany

IJERPH, 2022, vol. 19, issue 5, 1-10

Abstract: Background: Hypoglossal nerve palsy (HNP) is rather common as a neurological disease. However, as an isolated nerve palsy it is an exceedingly rare phenomenon and points at local pathologies along the peripheral course of the nerve. In this communication we report a granular cell tumor (GCT) arising in the submandibular segment of the hypoglossal nerve. Case-Report: Spontaneous isolated HNP was recognized in a female patient. First line MR-imaging identified a clivus-chordoma. However, involvement of the hypoglossal nerve was highly unlikely according to MR-findings. Finally, ultrasonographic investigation revealed a small submandibular mass which, at histological examination, turned out to be a granular cell tumor arising within the hypoglossal nerve. Conclusions: This is the report of an extremely rare GCT originating within the 12th cranial nerve. The case illustrates that isolated motoric cranial nerve palsy may result from this rare tumor entity. This report also points out the diagnostic value of a simple ultrasonographic investigation to depict pathologic lesions of the submandibular space.

Keywords: granular cell tumor; Abrikossoff; hypoglossal nerve; nerve palsy; tongue atrophy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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