The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress

Monika Fraczek, Angelika Lewandowska, Marta Budzinska, Marzena Kamieniczna, Lukasz Wojnar, Kamil Gill, Malgorzata Piasecka, Michal Kups, Anna Havrylyuk, Valentina Chopyak, Jozef Nakonechnyy, Andrij Nakonechnyy and Maciej Kurpisz
Additional contact information
Monika Fraczek: Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
Angelika Lewandowska: Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
Marta Budzinska: Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
Marzena Kamieniczna: Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
Lukasz Wojnar: Clinic of Urology and Oncological Urology, Poznan University of Medical Sciences, 61-285 Poznan, Poland
Kamil Gill: Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Malgorzata Piasecka: Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Michal Kups: Department and Clinic Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland
Anna Havrylyuk: Department of Clinical Immunology and Allergology, Danylo Halytskyy Lviv National Medical University, 79008 Lviv, Ukraine
Valentina Chopyak: Department of Clinical Immunology and Allergology, Danylo Halytskyy Lviv National Medical University, 79008 Lviv, Ukraine
Jozef Nakonechnyy: Department of Urology, Danylo Halytskyy Lviv National Medical University, 79010 Lviv, Ukraine
Andrij Nakonechnyy: Department of Paediatric Surgery, Danylo Halytskyy Lviv National Medical University, 79059 Lviv, Ukraine
Maciej Kurpisz: Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland

IJERPH, 2022, vol. 19, issue 5, 1-13

Abstract: Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) and ejaculated sperm chromatin/DNA integrity (DNA fragmentation and chromatin condensation abnormalities) in distinct groups of men exposed and not exposed to prolonged scrotal hyperthermia. A statistical increase in the proportion of sperm with DNA fragmentation was observed in all the studied subgroups compared to the fertile men. In turn, the groups subjected to heat stress as professional drivers or infertile men with varicocele presented greater disturbances in the oxidative stress scavenging system than men not exposed to genital heat stress. Based on the comparative analysis of the studied parameters, we can conclude that alterations in the seminal oxidative stress scavenging system are directly engaged in the pathogenesis of ejaculated sperm DNA damage regardless of the intensity of the impact of thermal insult. To the best of our knowledge, this study, for the first time, revealed the co-existence of oxidative stress and sperm DNA damage in the semen of professional drivers.

Keywords: genital heat stress; oxidative stress scavenging system; sperm DNA damage (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/5/2713/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/5/2713/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:5:p:2713-:d:758958

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().