Short-Term Air Pollution Exposure and Risk of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Korea: A National Time-Stratified Case-Crossover Study

Yun Jung Jung, Eun Jin Kim, Jung Yeon Heo, Young Hwa Choi, Dae Jung Kim and Kyoung Hwa Ha
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Yun Jung Jung: Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon 16499, Korea
Eun Jin Kim: Department of Infectious Diseases, Ajou University School of Medicine, Suwon 16499, Korea
Jung Yeon Heo: Department of Infectious Diseases, Ajou University School of Medicine, Suwon 16499, Korea
Young Hwa Choi: Department of Infectious Diseases, Ajou University School of Medicine, Suwon 16499, Korea
Dae Jung Kim: Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 16499, Korea
Kyoung Hwa Ha: Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 16499, Korea

IJERPH, 2022, vol. 19, issue 5, 1-10

Abstract: We investigated the association between short-term exposure to air pollution and the risk of acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) in seven metropolitan cities in Korea. We used national health insurance claims data to identify AE-COPD cases in 2015. We estimated short-term exposure to particulate matter (PM) with a diameter of ≤2.5 μm (PM 2.5 ), PM with diameters of ≤10 μm (PM 10 ), sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), carbon monoxide (CO), and ozone (O 3 ) obtained from the Ministry of Environment. We conducted a time-stratified, case-crossover study to evaluate the effect of short-term exposure to air pollution on hospital visits for AE-COPD, using a conditional logistic regression model. The risk of hospital visits for AE-COPD was significantly associated with interquartile range increases in PM 10 in a cumulative lag model (lag 0–2, 0.35%, 95% confidence interval (CI) 0.06–0.65%; lag 0–3, 0.39%, 95% CI 0.01–0.77%). The associations were higher among patients who were men, aged 40–64 years, with low household income, and with a history of asthma. However, other air pollutants were not significantly associated with the risk of hospital visits for AE-COPD. Short-term exposure to air pollution, especially PM 10 , increases the risk of hospital visits for AE-COPD.

Keywords: air pollution; acute exacerbation; chronic obstructive pulmonary disease; insurance claims (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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