Povidone-Iodine as a Pre-Procedural Mouthwash to Reduce the Salivary Viral Load of SARS-CoV-2: A Systematic Review of Randomized Controlled Trials

Alvaro Garcia-Sanchez, Juan-Francisco Peña-Cardelles, Esther Ordonez-Fernandez, María Montero-Alonso, Naresh Kewalramani, Angel-Orión Salgado-Peralvo, Dániel Végh, Angélica Gargano, Gabriela Parra, Lourdes-Isabela Guerra-Guajardo and Wataru Kozuma
Additional contact information
Alvaro Garcia-Sanchez: Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
Juan-Francisco Peña-Cardelles: Department of Health Sciences, Rey Juan Carlos University, 28040 Madrid, Spain
Esther Ordonez-Fernandez: Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
María Montero-Alonso: Pediatric Service, Hospital Álvaro Cunqueiro, 36213 Vigo, Spain
Naresh Kewalramani: Department of Nursery and Stomatology, Rey Juan Carlos University, 28922 Madrid, Spain
Angel-Orión Salgado-Peralvo: Department of Stomatology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain
Dániel Végh: Department of Prosthodontics, Semmelweis University, 1085 Budapest, Hungary
Angélica Gargano: Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
Gabriela Parra: Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
Lourdes-Isabela Guerra-Guajardo: Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
Wataru Kozuma: Department of Prosthodontics, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA

IJERPH, 2022, vol. 19, issue 5, 1-9

Abstract: The use of pre-procedural rinses has been investigated to reduce the number of viral particles and bacteria in aerosols, potentially decreasing the risk of cross-infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during medical and dental procedures. This review aims to confirm whether there is evidence in the literature describing a reduction in salivary load of SARS-CoV-2 when povidone-iodine (PVP-I) is used as a pre-intervention mouthwash. An search of the MEDLINE, Embase, SCOPUS, and the Cochrane library databases was conducted. The criteria used followed the PRISMA ® Statement guidelines. Randomized controlled trials investigating the reduction of salivary load of SARS-CoV-2 using PVP-I were included. Ultimately, four articles were included that met the established criteria. According to the current evidence, PVP-I is effective against SARS-CoV-2 in saliva and could be implemented as a rinse before interventions to decrease the risk of cross-infection in healthcare settings.

Keywords: COVID-19; SARS-CoV-2; mouthwashes; mouthrinse; aerosols; chlorhexidine; povidone-iodine; cetylpiridinium chloride; hydrogen peroxide; colony-forming units (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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