Assessing Entomological and Epidemiological Efficacy of Pyriproxyfen-Treated Ovitraps in the Reduction of Aedes Species: A Quasi-Experiment on Dengue Infection Using Saliva Samples

Antonio D. Ligsay, Kristan Jela M. Tambio, Michelle Joyce M. Aytona, Grecebio Jonathan D. Alejandro, Zypher Jude G. Regencia, Emmanuel S. Baja and Richard Edward L. Paul
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Antonio D. Ligsay: The Graduate School & College of Science, University of Santo Tomas España Boulevard, Manila 1008, Philippines
Kristan Jela M. Tambio: Clinical Research Section, St. Luke’s College of Medicine—William H. Quasha Memorial, 279 E. Rodriguez Sr. Ave, Quezon City 1112, Philippines
Michelle Joyce M. Aytona: Clinical Research Section, St. Luke’s College of Medicine—William H. Quasha Memorial, 279 E. Rodriguez Sr. Ave, Quezon City 1112, Philippines
Grecebio Jonathan D. Alejandro: The Graduate School & College of Science, University of Santo Tomas España Boulevard, Manila 1008, Philippines
Zypher Jude G. Regencia: Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila 1000, Philippines
Emmanuel S. Baja: Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila 1000, Philippines
Richard Edward L. Paul: Institut Pasteur, Functional Genetics of Infectious Diseases Unit, UMR 2000 (CNRS), 75015 Paris, France

IJERPH, 2022, vol. 19, issue 5, 1-13

Abstract: Our study assessed the impact of using ovitraps with pyriproxyfen on mosquito populations and the feasibility of using human saliva samples to test for seroconversion to dengue virus (DENV). We used a quasi-experimental research design by forming the intervention ( n = 220) and the control ( n = 223) groups in neighboring Taguig City, Philippines, over 4 months. Socio-demographic data, entomological indices, and IgG antibodies against DENV were measured. Associations between the implementation of ovitraps dosed with pyriproxyfen and mosquito densities (percentage positive ovitraps and container indices) and DENV seroconversion were calculated post-intervention in Months 2, 3, and 4. Among the participants recruited at baseline, 17 and 13 were seropositive for dengue (DENV) in the intervention and control groups, respectively. Both entomological indices were lower in the treated area than the control site at post-intervention Months 2, 3, and 4, but not earlier. Dengue seroconversions rates decreased in the treated population, but not significantly so. In conclusion, the use of PPF-treated ovitraps may have impacted the mosquito population, but not seroconversion rates. Compliance in providing saliva samples and the ability to detect IgG antibodies within these samples was encouraging and suggests that further studies on larger populations for longer durations are warranted.

Keywords: mosquito control; dengue; mosquito density; pyriproxyfen; Philippines (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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