Efficacy of MMP-8 Level in Gingival Crevicular Fluid to Predict the Outcome of Nonsurgical Periodontal Treatment: A Systematic Review

Sarhang Sarwat Gul, Faraedon Mostafa Zardawi, Ali Abbas Abdulkareem, Muhammad Saad Shaikh, Natheer Hashim Al-Rawi and Muhammad Sohail Zafar
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Sarhang Sarwat Gul: Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq
Faraedon Mostafa Zardawi: Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq
Ali Abbas Abdulkareem: Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad 10011, Iraq
Muhammad Saad Shaikh: Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi 75510, Pakistan
Natheer Hashim Al-Rawi: Department of Oral & Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates
Muhammad Sohail Zafar: Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madina, Al Munawwarra 41311, Saudi Arabia

IJERPH, 2022, vol. 19, issue 5, 1-14

Abstract: Purpose: To explore whether baseline matrix metalloproteinase (MMP)-8 level in gingival crevicular fluid (GCF) (exposure) can predict the outcome (reduction in probing pocket depth (PPD) (outcome)) of nonsurgical periodontal therapy (NSPT) (manual or ultrasonic or both) in patients with periodontitis (population/problem) after 3 months. Methods: Six databases (PubMed, Cochrane library, ProQuest, Ovid, Scopus, EBSCO) were searched for relevant articles published until 30 July 2021. Retrieved articles were passed through a three-phase filtration process on the basis of the eligibility criteria. The primary outcome was the change in PPD after 3 months. Quality of the selected articles was assessed using Cochrane Risk of Bias tool (RoB2) and Risk of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tools. Results: From 1306 articles, five were selected for analysis. The results showed high variations in the level of GCF MMP-8 level at baseline. The average amount of reduction in PPD was 1.20 and 2.30 mm for pockets with initial depth of 4–6 mm and >6 mm, respectively. Conclusion: On the basis of available evidence, it was not possible to reach a consensus on the ability of baseline GCF MMP-8 to forecast the outcome of NSPT. This could have been due to variation in clinical and laboratory techniques used. However, consistency in mean PPD reduction after 3 months was shown.

Keywords: matrix metalloproteinase-8; prediction; periodontitis; nonsurgical periodontal therapy; systematic review (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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