The Impact of Functional Bars and Adapted Physical Activity on Quality of Life in Chronic Kidney Disease: A Pilot Study

Elisa Grazioli, Eliana Tranchita, Giulia Marrone, Silvia Urciuoli, Manuela Di Lauro, Claudia Cerulli, Nicolò Piacentini, Arianna Murri, Roberto Celotto, Annalisa Romani, Attilio Parisi, Nicola Di Daniele and Annalisa Noce
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Elisa Grazioli: Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy
Eliana Tranchita: Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy
Giulia Marrone: UOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Silvia Urciuoli: PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), DiSIA, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Manuela Di Lauro: UOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Claudia Cerulli: Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy
Nicolò Piacentini: UOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Arianna Murri: Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy
Roberto Celotto: Department of Cardiovascular Disease, Tor Vergata University of Rome, 00133 Rome, Italy
Annalisa Romani: PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), DiSIA, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Attilio Parisi: Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy
Nicola Di Daniele: UOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Annalisa Noce: UOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

IJERPH, 2022, vol. 19, issue 6, 1-19

Abstract: Chronic kidney disease (CKD) represents a public health problem because it is characterized by several comorbidities, including uremic sarcopenia (US), and a poor quality of life. Currently, there are no standardized treatments available to counteract the onset of US but only some possible therapeutic approaches to slow its progression. The aim of this pilot study is to collect descriptive data in order to design a clinical trial based on the power analysis and simple size. The purpose of this pilot study was to evaluate the possible beneficial action induced by the functional anti-inflammatory and antioxidant bars in combination with the adapted physical activity (APA), on the onset and progression of US and other related-CKD comorbidities. We enrolled 21 CKD patients under conservative therapy, divided into four groups: (A) the physical exercise program (PEP), three times a week, in combination with the daily consumption of the two functional bars group; (B) the PEP group; (C) the daily consumption of the two functional bars group; (D) the control group. The duration of the study protocol was 12 weeks. We observed an improvement trend of body composition, blood pressure levels, lipid metabolism, and functional test in A and B groups. These preliminary data would seem to confirm the effectiveness of APA and to demonstrate the additive role of the natural bioactive compound’s assumption in countering US and other CKD comorbidities.

Keywords: chronic kidney disease; adapted physical activity; natural bioactive compounds; uremic sarcopenia; polyphenols (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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