Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Inmaculada Salcedo-Bellido, Esperanza Amaya, Celia Pérez-Díaz, Anabel Soler, Fernando Vela-Soria, Pilar Requena, Rocío Barrios-Rodríguez, Ruth Echeverría, Francisco M. Pérez-Carrascosa, Raquel Quesada-Jiménez, Piedad Martín-Olmedo and Juan Pedro Arrebola
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Inmaculada Salcedo-Bellido: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Esperanza Amaya: Instituto de Investigación Biosanitaria (ibs. GRANADA), 18014 Granada, Spain
Celia Pérez-Díaz: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Anabel Soler: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Fernando Vela-Soria: Instituto de Investigación Biosanitaria (ibs. GRANADA), 18014 Granada, Spain
Pilar Requena: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Rocío Barrios-Rodríguez: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Ruth Echeverría: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Francisco M. Pérez-Carrascosa: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain
Raquel Quesada-Jiménez: Instituto de Investigación Biosanitaria (ibs. GRANADA), 18014 Granada, Spain
Piedad Martín-Olmedo: Instituto de Investigación Biosanitaria (ibs. GRANADA), 18014 Granada, Spain
Juan Pedro Arrebola: Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain

IJERPH, 2022, vol. 19, issue 6, 1-16

Abstract: To identify bioaccumulation patterns of α-, β- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors, adipose tissue samples of 387 subjects from GraMo cohort in Southern Spain were analyzed. Potential predictors of these organochlorine pesticides (OCP) levels were collected by face-to-face interviews and assessed by multivariable linear and logistic regression. OCPs were detected in 84.2% (β-HCH), 21.7% (α-HCH), and 19.6% (dicofol) of the population. β-HCH levels were positively related to age, body mass index (BMI), mother’s occupation in agriculture during pregnancy, living in Poniente and Alpujarras, white fish, milk and water consumption, and negatively related to being male, living near to an agricultural area, working ≥10 years in agriculture, and beer consumption. Detectable α-HCH levels were positively related to age, BMI, milk consumption, mother’s occupation in agriculture during pregnancy, and negatively with residence in Poniente and Alpujarras, Granada city, and Granada Metropolitan Area. Residence near to an agricultural area, smoking habit, white fish and water consumption, and living in Poniente and Alpujarras, Granada city and Granada Metropolitan Area were negatively associated with detectable dicofol levels. Our study revealed different bioaccumulation patterns of α, β-HCH and dicofol, probably due to their dissimilar period of use, and emphasize the need for assessing the exposure to frequently overlooked pollutants.

Keywords: ?-hexachlorocyclohexane; ?-hexachlorocyclohexane; dicofol; human adipose tissue; exposure assessment; predictors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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