Serum Albumin Kinetics in Major Ovarian, Gastrointestinal, and Cervico Facial Cancer Surgery

Cyrus Motamed, Lucie Mariani, Stéphanie Suria and Gregoire Weil
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Cyrus Motamed: Department of Anesthesia, Institut de Cancerologie Gustave Roussy, 94080 Paris, France
Lucie Mariani: Department of Anesthesia and Intensive Care, APHP Hopital Pitié Salpétrière, 75013 Paris, France
Stéphanie Suria: Department of Anesthesia, Institut de Cancerologie Gustave Roussy, 94080 Paris, France
Gregoire Weil: Anesthesia Department, Centre Hospitalier d’Orleans, 45100 Orléans, France

IJERPH, 2022, vol. 19, issue 6, 1-11

Abstract: Hypoalbuminemia in major cancer surgery can lead to postoperative short and long-term complications. Our study was designed to detect albumin variations in three major cancer surgeries: ovarian debulking (DBK), major abdominal gastrointestinal surgery (ABD), and major cervico-facial, or ear, nose and throat cancer surgery (ENT). Single-center prospective study inclusion criteria were non-emergency procedures scheduled to last at least five hours. We performed hourly perioperative monitoring of the patients’ albuminemia and hemoglobinemia. Electronic charts were followed for at least five years for survival analysis. Sixty-three patients were analyzed: 30 in the DBK group, 13 in the ABD group, and 20 in the ENT group. There was a significant difference in albumin decrease between the ENT group and the two others (−19% at six hours in the ENT group versus -49% in the debulking group and −31% in the ABD group ( p < 0.05). There was no significant difference between the DBK and ABD groups. The decrease in hemoglobin was not significantly different between the groups, and no significant difference was observed in long-term survival. DBK and ABD surgery yielded significant hypoalbuminemia. Therefore, the extent of decrease in serum albumin is probably not the only etiology of the specific postoperative complications of these major surgeries. No significant difference was noticed in five-year mortality, and no correlation was found in relation to the degree of intraoperative albumin kinetics.

Keywords: major cancer surgery; serum albumin kinetics; albumin (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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