Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis

Valentin Brusseau, Igor Tauveron, Reza Bagheri, Ukadike Chris Ugbolue, Valentin Magnon, Jean-Baptiste Bouillon-Minois, Valentin Navel and Frédéric Dutheil
Additional contact information
Valentin Brusseau: Endocrinology Diabetology and Metabolic Diseases, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, F-63000 Clermont-Ferrand, France
Igor Tauveron: Endocrinology Diabetology and Metabolic Diseases, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, F-63000 Clermont-Ferrand, France
Reza Bagheri: Department of Exercise Physiology, University of Isfahan, Isfahan 81746-73441, Iran
Ukadike Chris Ugbolue: Institute for Clinical Exercise & Health Science, School of Health and Life Sciences, University of the West of Scotland, Glasgow G1 1XW, UK
Valentin Magnon: Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University of Clermont Auvergne, F-63000 Clermont-Ferrand, France
Jean-Baptiste Bouillon-Minois: Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University of Clermont Auvergne, F-63000 Clermont-Ferrand, France
Valentin Navel: Translational Approach to Epithelial Injury and Repair, GreD, CNRS, INSERM, University of Clermont Auvergne, F-63000 Clermont-Ferrand, France
Frédéric Dutheil: Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University of Clermont Auvergne, F-63000 Clermont-Ferrand, France

IJERPH, 2022, vol. 19, issue 6, 1-13

Abstract: Objective: Cardiovascular effects of thyroid hormones may be measured through heart rate variability (HRV). We sought to determine the impact of hyperthyroidism on HRV. Design: A systematic review and meta-analysis on the impact of hyperthyroidism on HRV. Methods: PubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hyperthyroidism and healthy controls. Random-effects meta-analysis was stratified by degree of hyperthyroidism for each HRV parameter: RR intervals (or Normal-to-Normal intervals—NN), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50 ms of variation), total power (TP), LFnu (low-frequency normalized unit) and HFnu (high-frequency), VLF (very low-frequency), and LF/HF ratio. Results: We included 22 studies with 10,811 patients: 1002 with hyperthyroidism and 9809 healthy controls. There was a decrease in RR (effect size = −4.63, 95% CI −5.7 to −3.56), SDNN (−6.07, −7.42 to −4.71), RMSSD (−1.52, −2.18 to −0.87), pNN50 (−1.36, −1.83 to −0.88), TP (−2.05, −2.87 to −1.24), HFnu (−3.51, −4.76 to −2.26), and VLF power (−2.65, −3.74 to −1.55), and an increase in LFnu (2.66, 1.55 to 3.78) and LF/HF ratio (1.75, 1.02 to 2.48) ( p < 0.01). Most parameters had ES that was twice as high in overt compared to subclinical hyperthyroidism. Increased peripheral thyroid hormones and decreased TSH levels were associated with lower RR intervals. Conclusions: Hyperthyroidism is associated with a decreased HRV, which may be explained by the deleterious effect of thyroid hormones and TSH. The increased sympathetic and decreased parasympathetic activity may have clinical implications.

Keywords: thyroid; biomarker; autonomic nervous activity; prevention; public health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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