Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Glaucia Schuindt Teixeira Neves, Gayathiri Elangovan, Mayla Kezy Silva Teixeira, João Martins de Mello-Neto, Santosh Kumar Tadakamadla, Eduardo José Veras Lourenço, Daniel Moraes Telles and Carlos Marcelo Figueredo
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Glaucia Schuindt Teixeira Neves: Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil
Gayathiri Elangovan: School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
Mayla Kezy Silva Teixeira: Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil
João Martins de Mello-Neto: School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
Santosh Kumar Tadakamadla: School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
Eduardo José Veras Lourenço: Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil
Daniel Moraes Telles: Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil
Carlos Marcelo Figueredo: School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia

IJERPH, 2022, vol. 19, issue 6, 1-12

Abstract: sTREM-1 and its ligand PGLYRP1 play an essential role in the inflammatory process around teeth and implants. In this study, we aimed to evaluate the impact of peri-implant treatment on the salivary levels of the sTREM-1/PGLYRP-1/MMP-8 axis after 3 months. A total of 42 participants (with a mean age of 61 years old ± 7.3) were enrolled in this longitudinal study, 24 having peri-implant mucositis (MU) and 18 having peri-implantitis (PI). Clinical peri-implant parameters, such as probing pocket depth (PPD), % of plaque, and bleeding on probing (BOP), and the whole unstimulated saliva samples were evaluated at baseline and 3 months after treatment. The MU group received nonsurgical peri-implant treatment, while the PI group received open-flap procedures. The levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 were analyzed using enzyme-linked immunosorbent assays. BOP, plaque levels, and PPD significantly reduced after treatment in both groups. A significant decrease in the salivary levels of sTREM-1, MMP-8, and TIMP-1 in the PI group and PGLYRP1 and TIMP-1 in the MU group were observed. Salivary levels of sTREM-1 were significantly reduced in patients with PI but not with MU. Additionally, peri-implant treatment had a significantly higher impact on MMP-8 reduction in patients with PI than in those with MU.

Keywords: sTREM-1; MMP-8; PGLYRP-1; peri-implant mucositis; peri-implantitis; peri-implant treatment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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