Correlation between Salivary Levels of IGF-1, IGFBP-3, IGF-1/IGFBP3 Ratio with Skeletal Maturity Using Hand-Wrist Radiographs

Abdullah Almalki, Julie Toby Thomas, Abdul Rehman Ahmed Khan, Basim Almulhim, Abdullah Alassaf, Sara Ayid Alghamdi, Betsy Joseph, Ali Alqerban and Saud Alotaibi
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Abdullah Almalki: Department of Preventive Dental Sciences (Orthodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Julie Toby Thomas: Department of Preventive Dental Sciences (Periodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Abdul Rehman Ahmed Khan: Department of Preventive Dental Sciences (Orthodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Basim Almulhim: Department of Preventive Dental Sciences (Pedodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Abdullah Alassaf: Department of Preventive Dental Sciences (Pedodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Sara Ayid Alghamdi: Department of Preventive Dental Sciences (Pedodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Betsy Joseph: Department of Periodontics, Saveetha Institute of Medical Sciences, Chennai 600077, India
Ali Alqerban: Department of Preventive Dental Sciences (Orthodontics), College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia
Saud Alotaibi: Department of Preventive Dental Sciences (Orthodontics), College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia

IJERPH, 2022, vol. 19, issue 6, 1-12

Abstract: Objective: The relevance of growth determination in orthodontics is driving the search for the most precise and least invasive way of tracking the pubertal growth spurt. Our aim was to explore whether minimally invasive salivary estimation of biomarkers Insulin-like growth factor (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) could be used to estimate skeletal maturity for clinical convenience, especially in children and adolescent age groups. Materials and Method: The cross-sectional study was conducted on 90 participants (56 girls and 34 males) with ages ranging from 6 to 25 years. Each subject’s hand-wrist radiograph was categorized based on skeletal maturity, and saliva samples were estimated for IGF-1 and IGFBP-3 using the respective ELISA kits. Kruskal–Wallis nonparametric ANOVA was applied to compare different skeletal stages. Results: The study demonstrated low salivary IGF-1 levels at the prepubertal stage, with increase during pubertal onset and peak pubertal stage followed by a decline during pubertal deceleration to growth completion. Spearman’s correlation coefficient demonstrated a strong positive association (r = 0.98 p < 0.01) between salivary IGF/IGFBP-3 ratio and different stages of skeletal maturity. Conclusion: Salivary IGF-1, IGFBP-3, and IGF/IGFBP-3 ratio could serve as a potential biochemical marker for predicting the completion of skeletal maturity.

Keywords: orthodontics; insulin-like growth factor; insulin-like growth factor binding protein; skeletal maturity; salivary diagnostics; hand wrist radiographs (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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