Laminar Necrosis and Hypoxic Damage of the Placenta: A Case-Control Study

Katia Mangialardi, Margherita Fanelli, Gerardo Cazzato, Andrea Marzullo, Maria Elisabetta Baldassarre, Antonella Vimercati and Leonardo Resta
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Katia Mangialardi: Department of Emergency and Organ Transplantation (DETO), Section of Pathology, School of Medicine University of Bari “Aldo Moro”, 70124 Bari, Italy
Margherita Fanelli: Department of Interdisciplinary Medicine, Medical Statistic, School of Medicine University of Bari “Aldo Moro”, 70124 Bari, Italy
Gerardo Cazzato: Department of Emergency and Organ Transplantation (DETO), Section of Pathology, School of Medicine University of Bari “Aldo Moro”, 70124 Bari, Italy
Andrea Marzullo: Department of Emergency and Organ Transplantation (DETO), Section of Pathology, School of Medicine University of Bari “Aldo Moro”, 70124 Bari, Italy
Maria Elisabetta Baldassarre: Department of Biomedical Sciences and Human Oncology, Neonatology and Neonatal Intensive Care Unit, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Antonella Vimercati: Department of Biomedical Sciences and Human Oncology, Gynecologic and Obstetrics Clinic, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Leonardo Resta: Department of Emergency and Organ Transplantation (DETO), Section of Pathology, School of Medicine University of Bari “Aldo Moro”, 70124 Bari, Italy

IJERPH, 2022, vol. 19, issue 7, 1-10

Abstract: The aim of this study is to verify the role of laminar necrosis (LN) in the diagnosis of hypoxic damage of the placenta. This is a retrospective case-control study in which 50 cases with laminar necrosis were compared with 100 gestational age-matched controls without laminar necrosis in a 1:2 ratio. The parameters analyzed were: the presence of other placental lesions, obstetric characteristics and neonatal outcome. For each of the 50 cases, the area affected by the lesion was detected, and the lesions were classified into three groups based on the morphology and time of onset of the lesion in order to understand whether these characteristics of the lesion had a clinical-pathology. The results showed that including the search for LN among placental lesions generally examined is useful to guide the pathologist in the diagnosis of placental dysfunction of hypoxic origin.

Keywords: placenta; laminar necrosis; placental dysfunction; placental lesions; hypoxic damage; pregnancy outcome (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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