Cardio-Pulmonary Dysfunction Evaluation in Patients with Persistent Post-COVID-19 Headache

Álvaro Aparisi, Cristina Ybarra-Falcón, Carolina Iglesias-Echeverría, Mario García-Gómez, Marta Marcos-Mangas, Gonzalo Valle-Peñacoba, Manuel Carrasco-Moraleja, César Fernández- de-las-Peñas, Ángel L. Guerrero and David García-Azorín
Additional contact information
Álvaro Aparisi: Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain
Cristina Ybarra-Falcón: Department of Cardiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
Carolina Iglesias-Echeverría: Department of Cardiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
Mario García-Gómez: Department of Cardiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
Marta Marcos-Mangas: Department of Cardiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
Gonzalo Valle-Peñacoba: Department of Neurology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
Manuel Carrasco-Moraleja: Department of Cardiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
César Fernández- de-las-Peñas: Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), 28922 Madrid, Spain
Ángel L. Guerrero: Department of Neurology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
David García-Azorín: Department of Neurology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain

IJERPH, 2022, vol. 19, issue 7, 1-10

Abstract: Background (1): Headache is a prevalent symptom experienced during ongoing SARS-CoV-2 infection, but also weeks after recovery. Whether cardio-pulmonary dysfunction contributes causally to headache persistence is unknown. Methods (2): We conducted a case-control analysis nested in a prospective cohort study. Individuals were recruited from August 2020 to December 2020. Patients were grouped according to the presence or absence of long-COVID headache for three months after COVID-19 resolution. We compared demographic data, clinical variables, cardio-pulmonary laboratory biomarkers, quality of life, and cardio-pulmonary function between groups. Results (3): A cohort of 70 COVID-19 patients was evaluated. Patients with headaches (n = 10; 14.3%) were more frequently female (100% vs. 58.4%; p = 0.011) and younger (46.9 ± 8.45 vs. 56.13 ± 12 years; p = 0.023). No between-group differences in laboratory analysis, resting echocardiography, cardio-pulmonary exercise test, or pulmonary function tests were observed. Conclusion (4): In this exploratory study, no significant differences in cardio-pulmonary dysfunction were observed between patients with and without long-COVID headache during mid-term follow-up.

Keywords: long-COVID syndrome; cardio-pulmonary exercise testing; headache disorders; COVID-19 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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