Association of KMT2C Genetic Variants with the Clinicopathologic Development of Oral Cancer

Mu-Kuei Shieu, Hsin-Yu Ho, Shu-Hui Lin, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Ming-Ju Hsieh and Mu-Kuan Chen
Additional contact information
Mu-Kuei Shieu: Division of General Practice, Department of Medical Education, Changhua Christian Hospital, Changhua 500, Taiwan
Hsin-Yu Ho: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Shu-Hui Lin: Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan
Yu-Sheng Lo: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Chia-Chieh Lin: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Yi-Ching Chuang: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Ming-Ju Hsieh: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Mu-Kuan Chen: Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan

IJERPH, 2022, vol. 19, issue 7, 1-10

Abstract: Lysine methyltransferase 2C (KMT2C) is a tumor-suppressor gene in several myeloid cells and epithelia and is linked with blood and solid tumor cancers. KMT2C single-nucleotide polymorphisms (SNPs) are also connected with several cancer types. Our study aimed to explore the potential genetic polymorphisms of KMT2C in oral cancer. Five KMT2C SNPs, including rs201834857, rs4725443, rs6464221, rs74483926, and rs6943984, were evaluated in 284 cancer-free controls and 284 oral squamous cell carcinoma (OSCC) cases. We found that individuals with the TC genotype or TC + CC genotype of rs4725443 had a higher risk of oral cancer incidence than those with the TT genotype. Further analysis of KMT2C SNP rs4725443 revealed that the TC + CC genotype of rs4725443 was associated with a significantly advanced tumor stage in the non-alcohol-drinking population. Moreover, the TC + CC genotype of rs4725443 was connected with poor cell differentiation in the alcohol-drinking population. Through analyzing a dataset from The Cancer Genome Atlas (TCGA), we found that reduced KMT2C levels were associated with advanced tumor stage, lymph node invasion, and poor cell differentiation in head and neck squamous cell carcinomas. Our data suggest that KMT2C SNP rs4725443 is a potential genetic marker for oral cancer patients in both non-alcohol-drinking and alcohol-drinking populations.

Keywords: oral squamous cell carcinoma; lysine methyltransferase 2C; single-nucleotide polymorphisms; alcohol drinking (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/7/3974/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/7/3974/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:7:p:3974-:d:780604

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().