Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study

Pi-Ching Yu, Ren-Jei Chung, Yao-Ching Huang, Shi-Hao Huang, Bing-Long Wang, Wu-Chien Chien, Chi-Hsiang Chung, Chien-An Sun, Sung-Sen Yang and Gwo-Jang Wu
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Pi-Ching Yu: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan
Ren-Jei Chung: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
Yao-Ching Huang: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
Shi-Hao Huang: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
Bing-Long Wang: School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
Wu-Chien Chien: Department of Medical Research, Tri-Service General Hospital, Taipei 11490, Taiwan
Chi-Hsiang Chung: Department of Medical Research, Tri-Service General Hospital, Taipei 11490, Taiwan
Chien-An Sun: Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan
Sung-Sen Yang: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan
Gwo-Jang Wu: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan

IJERPH, 2022, vol. 19, issue 7, 1-12

Abstract: Objectives : To investigate whether chronic obstructive pulmonary disease (COPD) affects nonapnea sleep disorder (NASD) on the risk of obesity. Materials and Methods : From 1 January 2000 to 31 December 2015, a total of 24,363 patients with obesity from the 2005 Longitudinal Health Insurance Database were identified; 97,452 patients without obesity were also identified from the same database. Multiple logistic regression was used to analyze the previous exposure risk of patients with obesity and NASD. A p value of <0.05 was considered significant. Results : The risk of developing obesity in patients with COPD is 3.05 times higher than that in patients without COPD. Patients with COPD with NASD had a 1.606-fold higher risk of developing obesity than those without NASD. Patients with obesity were more likely to be exposed to NASD than did those without obesity (adjusted odds ratio, 1.693; 95% confidence interval, 1.575–1.821, p < 0.001). Furthermore, the closeness of the exposure period to the index time was positively associated with the severity of obesity, with a dose–response effect. The exposure duration of NASD in patients with obesity was 1.693 times than that in those without obesity. Longer exposure durations were associated with more severe obesity, also with a dose–response effect. Conclusions : The COPD effect of NASD increases the subsequent risk of obesity, and the risk of obesity was determined to be significantly higher in patients with NASD in this case–control study. Longer exposure to NASD was associated with a higher likelihood of obesity, also with a dose–response effect.

Keywords: nonapnea sleep disorder; chronic obstructive pulmonary disease; obesity; National Health Insurance Research Database; case–control study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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