Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males

Gabriele Mulliri, Sara Magnani, Silvana Roberto, Giovanna Ghiani, Fabio Sechi, Massimo Fanni, Elisabetta Marini, Silvia Stagi, Ylenia Lai, Andrea Rinaldi, Raffaella Isola, Romina Vargiu, Marty D. Spranger and Antonio Crisafulli
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Gabriele Mulliri: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy
Sara Magnani: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy
Silvana Roberto: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy
Giovanna Ghiani: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy
Fabio Sechi: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy
Massimo Fanni: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy
Elisabetta Marini: Department of Life and Environmental Sciences, University of Cagliari (Italy), 09124 Cagliari, Italy
Silvia Stagi: Department of Life and Environmental Sciences, University of Cagliari (Italy), 09124 Cagliari, Italy
Ylenia Lai: Department of Biomedical Sciences, University of Cagliari (Italy), 09124 Cagliari, Italy
Andrea Rinaldi: Department of Biomedical Sciences, University of Cagliari (Italy), 09124 Cagliari, Italy
Raffaella Isola: Department of Biomedical Sciences, University of Cagliari (Italy), 09124 Cagliari, Italy
Romina Vargiu: Department of Biomedical Sciences, University of Cagliari (Italy), 09124 Cagliari, Italy
Marty D. Spranger: Department of Physiology, Michigan State University, East Lansing, MI 48823, USA
Antonio Crisafulli: Department of Medical Sciences and Public Health, University of Cagliari (Italy), 09124 Cagliari, Italy

IJERPH, 2022, vol. 19, issue 8, 1-13

Abstract: Hemodynamic changes during exercise in acute hypoxia (AH) have not been completely elucidated. The present study aimed to investigate hemodynamics during an acute bout of mild, dynamic exercise during moderate normobaric AH. Twenty-two physically active, healthy males (average age; range 23–40 years) completed a cardiopulmonary test on a cycle ergometer to determine their maximum workload (W max ). On separate days, participants performed two randomly assigned exercise tests (three minutes pedaling at 30% of W max ): (1) during normoxia (NORMO), and (2) during normobaric AH at 13.5% inspired oxygen (HYPO). Hemodynamics were assessed with impedance cardiography, and peripheral arterial oxygen saturation (SatO 2 ) and cerebral oxygenation (Cox) were measured by near-infrared spectroscopy. Hemodynamic responses (heart rate, stroke volume, cardiac output, mean arterial blood pressure, ventricular emptying rate, and ventricular filling rate) were not any different between NORMO and HYPO. However, the HYPO test significantly reduced both SatO 2 (96.6 ± 3.3 vs. 83.0 ± 4.5%) and Cox (71.0 ± 6.6 vs. 62.8 ± 7.4 A.U.) when compared to the NORMO test. We conclude that an acute bout of mild exercise during acute moderate normobaric hypoxia does not induce significant changes in hemodynamics, although it can cause significant reductions in SatO 2 and Cox.

Keywords: blood pressure; cardiac output; stroke volume; ventricular filling rate; ventricular emptying rate (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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