Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality

Aleksandra Suchanecka, Jolanta Chmielowiec, Krzysztof Chmielowiec, Grzegorz Trybek, Aleksandra Jaroń, Wojciech Czarny, Paweł Król, Jolanta Masiak and Anna Grzywacz
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Aleksandra Suchanecka: Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland
Jolanta Chmielowiec: Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Zyty 28 St., 65-046 Zielona Gora, Poland
Krzysztof Chmielowiec: Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Zyty 28 St., 65-046 Zielona Gora, Poland
Grzegorz Trybek: Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstanców Wlkp. St., 70-111 Szczecin, Poland
Aleksandra Jaroń: Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstanców Wlkp. St., 70-111 Szczecin, Poland
Wojciech Czarny: Faculty of Physical Education, University of Rzeszów, Towarnickiego 3 St., 35-959 Rzeszów, Poland
Paweł Król: College of Medical Sciences, Institute of Physical Culture Studies, University of Rzeszow, St. Towarnickiego 3, 35-955 Rzeszów, Poland
Jolanta Masiak: Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, 20-093 Lublin, Poland
Anna Grzywacz: Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland

IJERPH, 2022, vol. 19, issue 8, 1-14

Abstract: We nowadays record growing numbers of e-cigarette users. The development of nicotine dependence is a result of many factors, including genetics and personality. In this study we analyzed two polymorphisms—rs1985242 and rs1062613—in the serotonin receptor HTR3A gene in a group of e-cigarette users ( n = 135) and controls ( n = 106). Personality traits were measured using the NEO Five-Factor Inventory. The comparison of e-cigarette users with the control group indicates that the former showed significantly higher scores on the neuroticism scale and lower scores on the scales of extraversion and conscientiousness of the NEO-FFI. Homozygote variants of rs1985242 were more frequent in the study group. The results of the 2 × 3 factorial ANOVA for e-cigarette users and the control group as well as interaction between the HTR3A rs1985242 variants were found for the NEO-FFI conscientiousness scale. These results allow us to conclude that the combination of psychological factors and genetic data creates a possibility for making more complete models of substance use disorders.

Keywords: nicotine addiction; serotonin receptor; personality traits; genetics (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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