Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe

Jordi Rubió-Casadevall, Elna Ciurana, Montserrat Puigdemont, Arantza Sanvisens, Jordi Marruecos, Josefina Miró, Antoni Urban, Rosa-Lisset Palhua, Ferran Martín-Romero, Maria Rosa Ortiz-Duran and Rafael Marcos-Gragera
Additional contact information
Jordi Rubió-Casadevall: Medical Oncology Department, Catalan Institute of Oncology, Hospital Josep Trueta, 17007 Girona, Spain
Elna Ciurana: School of Medicine, University of Girona (UdG), 17004 Girona, Spain
Montserrat Puigdemont: Descriptive Epidemiology, Genetics and Cancer Prevention Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain
Arantza Sanvisens: Descriptive Epidemiology, Genetics and Cancer Prevention Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain
Jordi Marruecos: School of Medicine, University of Girona (UdG), 17004 Girona, Spain
Josefina Miró: Pathology Department, Girona Clinic, 17007 Girona, Spain
Antoni Urban: Pathology Department, Corporació de Salut del Maresme La Selva, Hospital Sant Jaume de Calella, 08370 Barcelona, Spain
Rosa-Lisset Palhua: Pathology Department, Serveis de Salut Integrats Baix Empordà, Palamos Hospital, 17230 Girona, Spain
Ferran Martín-Romero: Pathology Department, Fundació Salut Emporda, Figueres Hospital, 17600 Girona, Spain
Maria Rosa Ortiz-Duran: School of Medicine, University of Girona (UdG), 17004 Girona, Spain
Rafael Marcos-Gragera: Descriptive Epidemiology, Genetics and Cancer Prevention Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain

IJERPH, 2022, vol. 19, issue 8, 1-13

Abstract: Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. Methods: We analyzed the epidemiology of OPC using the database from Girona’s population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997–1999, 2003–2005, 2009–2011, and 2016–2018. Results: Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016–2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Conclusions: Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC.

Keywords: oropharyngeal cancer; epidemiology; survival; incidence; p16; human papilloma virus (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/8/4802/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/8/4802/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:8:p:4802-:d:794557

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().