Evaluation of Celiac Disease by Minimally Invasive Biomarkers in a Spanish Pediatric Population

Julia María Cabo del Riego, María Jesús Núñez Iglesias, Carmen García-Plata González, José Paz Carreira, Tamara Álvarez Fernández, Ana Dorado Díaz, Noa Villar Mallo, Manuel Penedo Pita, Silvia Novío Mallón, Lola Máiz Suárez and Manuel Freire-Garabal Núñez
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Julia María Cabo del Riego: Clinical Analysis Laboratory, Department of Inmunology, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
María Jesús Núñez Iglesias: Department of Psiquiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15705 A Coruña, Spain
Carmen García-Plata González: Pediatric Gastrohepathology Unit of Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
José Paz Carreira: Pediatric Gastrohepathology Unit of Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
Tamara Álvarez Fernández: Clinical Analysis Laboratory, Department of Inmunology, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
Ana Dorado Díaz: Department of Statistical Health Counselling, Junta de Castilla y León, 47001 Valladolid, Spain
Noa Villar Mallo: Clinical Analysis Laboratory, Department of Inmunology, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
Manuel Penedo Pita: Clinical Analysis Laboratory, Department of Inmunology, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
Silvia Novío Mallón: Department of Psiquiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15705 A Coruña, Spain
Lola Máiz Suárez: Clinical Analysis Laboratory, Department of Inmunology, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
Manuel Freire-Garabal Núñez: SNL Laboratory, School of Medicine and Dentistry, 15782 A Coruña, Spain

IJERPH, 2022, vol. 19, issue 9, 1-11

Abstract: Background: The diagnosis of celiac disease (CD) has been substantially improved with the availability of highly sensitive CD-specific IgA-TG2, Ig-GDP, and IgA-EMA. The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) published (2012) and updated (2020) diagnostic criteria for CD in order to simplify CD diagnosis and to avoid biopsies in selected patients. Methods: A prospective study including 5641 pediatric patients (0–16 years old) from January 2012 to January 2019 was performed. CD diagnosis was made according to the ESPGHAN algorithm. The objective of this study was to evaluate the utility of biomarkers and the relationship between TGA-IgA and EMA titers. Results: CD diagnoses were confirmed in 113 patients, 110 were IgA-TG2-positive and 3 (2.7%) had IgA deficiency. The diagnosis was made by serologic tests in 95 (84.1%) patients. Only 18 (15.9%) patients underwent intestinal biopsy. We obtained 100% concordance between IgA-EMA and positive results for IgA-TG2 ≥ 10 ULN with IgA-EMA antibody titer ≥ 1:80. Conclusions: This study provides evidence of a positive correlation between IgA-TG2 antibody serum levels and IgA-EMA. The diagnosis could be guaranteed with strict application of IgA-TG2 values ≥ 10 ULN (confirmed by subsequent testing) plus the serological response to the gluten-free diet (GFD).

Keywords: non-invasive biomarkers; celiac disease; ESPGHAN; diagnosis; antibodies; pediatric age (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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